UNT BIOL 3451 - Genetic Mapping in Eukaryotes (6 pages)

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Genetic Mapping in Eukaryotes



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Genetic Mapping in Eukaryotes

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A look at gene linkage, different types of crossovers, and genetic mapping in eukaryotes.


Lecture number:
7
Pages:
6
Type:
Lecture Note
School:
University of North Texas
Course:
Biol 3451 - Genetics
Edition:
1
Documents in this Packet

Unformatted text preview:

BIOL 3451 1st Edition Lecture 7 Outline of Last Lecture I 4 8 Phenotypes Are Often Affected by More Thank One Gene II 4 9 Complementation Analysis Can Determine If Two Mutations Causing a Similar Phenotype Are Alleles of the Same Gene III 4 10 Expression of a Single Gene May Have Multiple Effects IV 4 11 X Linkage Describes Genes on the X Chromosome V 4 12 Sex Limited and Sex Influenced Inheritance and Individual s Sex Influences the Phenotype VI 4 13 Genetic Background and the Environment May Alter Phenotypic Expression Outline of Current Lecture I 4 13 Genetic Background and the Environment May Alter Phenotypic Expression II 5 1 Genes Linked on the Same Chromosome Segregate Together III 5 2 Crossing Over Serves as the Basis of Determining the Distance between Genes in Chromosome Mapping IV 5 3 Determining the Gene Sequence during Mapping Requires the Analysis of Multiple Crossovers V 5 4 As the Distance between Two Genes Increases Mapping Estimates Become More Inaccurate VI 5 5 Drosophila Genes Have Been Extensively Mapped VII 5 6 Lod Score Analysis and Somatic Cell Hybridization Were Historically Important in Creating Human Chromosome Maps VIII 5 7 Chromosome Mapping is Now Possible Using DNA Markers and Annotated Computer Databases Current Lecture I 4 13 Genetic Background and the Environment May Alter Phenotypic Expression Delayed onset of phenotypic expression i Tay Sachs disease 1 Autosomal disease 2 Baby normal for a few months dies by age 3 ii Lesch Nyhan syndrome 1 X linked recessive 2 Purine salvage enzyme defect 3 Normal for about 6 months These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute II iii Duchene muscular dystrophy 1 X linked recessive 2 Diagnosis at 3 5 years old Genetic Anticipation i Phenomenon in which genetic disease appears earlier and the size of the repeated segment increases with each succeeding generation 1 Huntington disease myotonic



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