UT Arlington BIOL 3315 - geneticlecture1 (13 pages)

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Free genetics tutoring provided by the biology department sunday room 100ls 8am 10am genetics open 10am 2pm genetics tutoring 1 27 2014 syed abbas sunday 8 10 Daren card mon 8 30 10 ERB444 WEd 8 30 10 ERB444 Drew tue wen 4 6 Chapter 2 notes Gene Dystrophin can occur naturally in other species dogs cats mice they are good experimental models to test the gene and find out how to prevent it Mb mega bases it has a big mega bases 2 5Mb Transcribed from RNA Most common inherited dystrophies Dystrophin gene function Actin Cytoskeleton in dog models very often there s mutation that actually work in causing inappropriate splicing causes exon to be skipped including exon that have the defective mutation X chromosome in 3 species The cat x chromosome is similar to the human the genes are organized in the same order Mouse only has a handful of genes that are similar in order and compatibility Synteny is conserved in mouse Synteny is the conserved order of genes in the x chromosome sequence Genome Evolution synteny map color coding shows us that there are similar gene structure in the chromosome comparing human and mouse The X chromosome are identical in human and mouse although Most of the Differences appeared in the time of differences in rodents and primates But for some reason these changes in the chromosomes do not appear in the X WHY NOT THE X WHY IS SO CONSERVED we don t know at this point Chapter 3 Notes Gene Function PKU what is PKU an inherited metabolic disorder by mutations in gene encoding phenylalanine can cause a many different problems in infants block metabolic pathway 1 phenylalanine will accumulate 2 phenylpyruvate will accumulate and depending on diet there may also be a deficiency in tyrosine If Pku is detected then the diet can be changed and remove phenylalanine from diet and prevent many problems one being severe brain damage Pku is not controversial but the testing of newborns are controversial why Y414y Y tyrosine so at Y 414 tyrosine has mutated to