UNC-Chapel Hill EXSS 276 - Endocrine System Part 2 (5 pages)

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Endocrine System Part 2

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Endocrine System Part 2


Continuation of the Endocrine System

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University of North Carolina at Chapel Hill
Exss 276 - Human Physiology

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1st Edition EXSS 276 Lecture 11 Outline of Last Lecture I Hormone Regulation in Blood II Hypothalamus and Pituitary Glands Master Glands III Targets and Functions of Pituitary Hormones IV The Endocrine System Stress Metabolic Water Electrolyte Balance Hormones Outline of Current Lecture I Adrenal Cortex II Metabolic Hormones III Diabetes Mellitus IV Human Growth Hormone hGH and Insulin like Growth Factors IGF Current Lecture I Adrenal Cortex a Three zones i Middle layer zona fasciculate secretes glucocorticoids b Cortisol i Most abundant of glucocorticoids ii Secreted by adrenal cortex under control of hypothalamic pituitary axis iii Stimuli for release 1 Emotional stress 2 Physical stress trauma 3 Exercise 4 Decreased blood glucose levels iv Metabolic effects 1 Breakdown of protein to amino acids in the muscle 2 Hepatic gluconeogenesis 3 Increased lipolysis v Cardiovascular effects 1 Increase blood vessel sensitivity to hormone induced vasoconstriction vi Immune system effects 1 Inhibits WBC that participate in inflammatory responses 2 Depresses other immune system responses vii Regulation of Cortisol These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute II 1 Releasing hormone out of hypothalamus corticotropin releasing hormone 2 Pituitary releasing hormone Adrenocorticotropin 3 Stimulates adrenal cortex 4 Negative feedback loop viii Medical Problems 1 Cushing s Syndrome a Hormonal disorder caused by prolonged exposure of body tissues to high levels of cortisol b Mostly affects 20 50 year olds c Only 10 15 out of every million people affected rare d Symptoms i Upper body obesity ii Thin and fragile skin and fragile bones iii Weakness fatigue irritation high blood glucose high BP e Treatments i Taper doses of glucocorticoids ii Removal of tumors iii Drugs in inhibit cortisol synthesis 2 Addison s Disease autoimmune disease a Adrenal insufficiency b Opposite of Cushing

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