IUB BIOL-L 211 - The Nucleosome (4 pages)

Previewing page 1 of 4 page document View the full content.
View Full Document

The Nucleosome

Previewing page 1 of actual document.

View the full content.
View Full Document
View Full Document

The Nucleosome


The Nucleosome

Lecture number:
Lecture Note
Indiana University, Bloomington
Biol-L 211 - Molecular Biology
Documents in this Packet

Unformatted text preview:

BIOL L 211 Lecture 7 Outline of Last Lecture I Cell Division II Interphase III Mitosis IV Meiosis Outline of Current Lecture I Articles II Histones III Nucleosome Current Lecture The Nucleosome I Articles A Hello Mothers Hello Father The Economist Oct 2012 1 Subject Matter Mitochondrial transplantation 2 Mitochondria have unique set of chromosomes Mitochondrial DNA mtDNA 3 Procedure a Eggs donated from people some with healthy some with mutated mitochondria b The nuclei of the eggs healthy and unhealthy were removed c Nucleus from the healthy egg was discarded while the nucleus from the diseased egg was moved to the healthy nucleus free egg d New egg with mixed DNA fertilized These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute e Resulting embryo had genetic information from 3 people B Grandma s Curse The Economist Nov 2012 1 Epigenetics studies gene expression 2 Smoking effects seem to be passed on skipping a generation 3 Experiment a Rats exposed to nicotine b Progeny tracked for health effects c Results 2 generations away asthmatic traits present d Conclusion inherited H3 acetylation causes asthmatic lungs i In general RGZ protects lungs against nicotine ii RGZ blocks H3 acetylation II Histones Compact DNA so that it can fit in nucleus A 5 Main Histone Proteins 1 H2A H2B H3 and H4 can form an intermediate structure when not bound to DNA because of a unique histone fold domain a Domain Structure helix turn helix turn helix HTHTH structure 2 H1 Linker histone B Histone Charges 1 Histone charges determine if chromosomes are condensed or de condensed 2 VERY relevant to the cell cycle 3 Histone DNA interaction is determined by charge NOT SEQUENCE and is not permanent 4 DNA is negatively charged because of its phosphate backbone thus gene expression is controlled by the nature of histones which 5 Note that modifications to histone fold domain are reversible and do NOT

View Full Document

Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...

Join to view The Nucleosome and access 3M+ class-specific study document.

We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view The Nucleosome and access 3M+ class-specific study document.


By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?