IUB BIOL-L 211 - The Nucleosome (4 pages)
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The Nucleosome
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The Nucleosome
- Lecture number:
- 7
- Pages:
- 4
- Type:
- Lecture Note
- School:
- Indiana University, Bloomington
- Course:
- Biol-L 211 - Molecular Biology
- Edition:
- 1
Documents in this Packet
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4 pages
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21 pages
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Lecture 37: Molecular Biology Techniques II
3 pages
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Lecture 36: Molecular Biology Techniques I
3 pages
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Lecture 35: Protein Purification
2 pages
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11 pages
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Lecture 34: Signal Transduction
4 pages
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4 pages
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Lecture 33: Protein Sorting and Localization
4 pages
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3 pages
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Lecture 30: Introduction to Translation
3 pages
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Lecture 29: Introduction to Genetic Code
3 pages
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11 pages
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2 pages
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Lecture 27: RNA Splicing and Regulatory RNAs
3 pages
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3 pages
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Lecture 25: Epigenetics (cont.) and RNA Splicing
4 pages
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Lecture 24: Transcriptional Regulation in Eukaryotes and Epigenetics
3 pages
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Lecture 23: Transcriptional Regulation in Eukaryotes
4 pages
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Lecture 22: Transcription in Eukaryotes II and Transcriptional Regulation in Eukaryotes I
4 pages
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Lecture 21: Transcription in Eukaryotes I.5
3 pages
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Lecture 20: Transcription in Eukaryotes
4 pages
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8 pages
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Lecture 19: Transcriptional Regulation in Prokaryotes II
3 pages
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Lecture 18: Transcriptional Regulation in Prokaryotes I
3 pages
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Lecture 17: Transcription in Prokaryotes II
3 pages
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Lecture 16: Transcription in Prokaryotes I
3 pages
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Lecture 15: RNA: Introduction to Transcription
3 pages
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Lecture 14: Double-Stranded Breaks and Repair Mechanisms
3 pages
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Lecture 13: Chemical and Environmental Mutagens and Cellular Damage Mechanisms
4 pages
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Lecture 12: Replication Errors and the Mismatch Repair System
3 pages
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9 pages
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Lecture 11: Replication Initiation
3 pages
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Lecture 10: PCR, DNA Sequencing, and Restriction Endonucleases
3 pages
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3 pages
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3 pages
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3 pages
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Lecture 5: DNA and Transposons
3 pages
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Lecture 4: Bacteria and Bacteriophage
4 pages
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Lecture 3: Drosophila as a Model System
3 pages
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3 pages
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Lecture 1: New Life for Ancient DNA
2 pages
Unformatted text preview:
BIOL L 211 Lecture 7 Outline of Last Lecture I Cell Division II Interphase III Mitosis IV Meiosis Outline of Current Lecture I Articles II Histones III Nucleosome Current Lecture The Nucleosome I Articles A Hello Mothers Hello Father The Economist Oct 2012 1 Subject Matter Mitochondrial transplantation 2 Mitochondria have unique set of chromosomes Mitochondrial DNA mtDNA 3 Procedure a Eggs donated from people some with healthy some with mutated mitochondria b The nuclei of the eggs healthy and unhealthy were removed c Nucleus from the healthy egg was discarded while the nucleus from the diseased egg was moved to the healthy nucleus free egg d New egg with mixed DNA fertilized These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute e Resulting embryo had genetic information from 3 people B Grandma s Curse The Economist Nov 2012 1 Epigenetics studies gene expression 2 Smoking effects seem to be passed on skipping a generation 3 Experiment a Rats exposed to nicotine b Progeny tracked for health effects c Results 2 generations away asthmatic traits present d Conclusion inherited H3 acetylation causes asthmatic lungs i In general RGZ protects lungs against nicotine ii RGZ blocks H3 acetylation II Histones Compact DNA so that it can fit in nucleus A 5 Main Histone Proteins 1 H2A H2B H3 and H4 can form an intermediate structure when not bound to DNA because of a unique histone fold domain a Domain Structure helix turn helix turn helix HTHTH structure 2 H1 Linker histone B Histone Charges 1 Histone charges determine if chromosomes are condensed or de condensed 2 VERY relevant to the cell cycle 3 Histone DNA interaction is determined by charge NOT SEQUENCE and is not permanent 4 DNA is negatively charged because of its phosphate backbone thus gene expression is controlled by the nature of histones which 5 Note that modifications to histone fold domain are reversible and do NOT
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BIOL-L 211: DNA REPLICATION
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