Mizzou MICROB 3200 - Adaptive Immunity and Immunization (7 pages)

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Adaptive Immunity and Immunization

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Adaptive Immunity and Immunization


Notes from class

Lecture number:
Lecture Note
University of Missouri
Microb 3200 - Medical Microbiology and Immunology

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MICROB 3200 1nd Edition Lecture 6 Outline of Current Lecture 1 Adaptive Immunity a Immune responses and protection b The structure of the B T cell antigen receptor and the classes of T lymphocytes c To discuss antigen processing presentation d Cytokine production and function e To discuss the interactions between lymphocyte populations required for the induction of either a humoral or cell mediated immune response f Memory development 2 Immunization a To identify several clinical applications of the mechanisms of protective immunity b Classify vaccine types and the limitations associated with each c Introduce the concept of passive immunity and the production of monoclonal antibodies d To discuss the value of immune testing in the clinic or laboratory e Brief discussion of immune therapies Current Lecture Adaptive Immunity How do we get from antigen recognition to effector function Binding of antigen receptor BCR or TCR to antigen signals the activation proliferation and differentiation of lymphocytes T cells effector function killing CD8 and cytokine expression CD8 and CD4 TCR and co receptor bind pMHCmolecules B cells antibody production BCR bind protein or peptide antigen Major Histocompatibility Complex MHC Proteins expressed on the surface of cells that present fragments of proteins derived from either exogenous or endogenous antigens Two major types of MHC molecules Class I molecules found on all nucleated cells Class II molecules found on antigen presenting cells APCs Play a critical role in defining the type of adaptive immune response Types of T Lymphocytes 2 major types CD4 T Lymphocytes 2 types of helper T cells These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute CD8 T Lymphocytes Cytotoxic T cells CD4 CD8 represent surface markers that are used to identify specific T cell populations more importantly they serve as co receptor molecules to recognize MHC

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