Mizzou MICROB 3200 - Innate immunity (35 pages)

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BIOM 121 1nd Edition Lecture 7 Outline of Current Lecture 1 Innate Immunity a Modes of defense b Complements c Pattern Recognition Receptors d Inflammation Current Lecture Innate Immunity Part 2 Chapter 15 Lecture 2 Innate immunity up till now we left you at phagocytosis to review A pathogen can cause disease only if it can Gain access to the body either by penetrating the skin or entering through an alternate portal of entry Attach itself to host cells Evade the host defense systems long enough to cause harmful changes Innate immune responses have two basic goals Direct action immediate Prevent the entry proliferation of pathogens Directly kill invading pathogens Indirect action immediate and delayed Induce inflammation Establish determine regulate the type of immune response o So we don t bring a knife to a gun fight Activate and recruit the appropriate adaptive immune response Used as communication to bridge innate adaptive immune responses These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Components of the Second Line of Defense Phagocytic cells neutrophils macrophages and eosinophils utilize intracellular killing mechanisms after antigen capture o dendritic cells capture antigens traffic to the LN and present antigen to naive T cells o Neutrophils are usually first they have good half life Specific innate leukocytes eosinophils natural killer NK cells can kill by extracelluar mechanisms Serum proteins including complement participates in the second line of defense o Directly kill pathogens o Activate inflammation Complement Set of serum proteins designated numerically according to the order of their discovery Complement activation has three biological effects inflammation opsonization phagocytosis and cell lysis o Inflammation o Oponization phagocytosis o Cell lysis Move C3B o Can bind to form final protein in cascade o Something else o Without it kids don t