WSU PSYCH 265 - Addiction (3 pages)

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Addiction and relapse

Lecture number:
Lecture Note
Washington State University
Psych 265 - biopsychological effect

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PSYCH 265 1st Edition Lecture 6 Outline of Last Lecture I Cerebral cortex II Thalamus III Hypothalamus IV Cerebellum V RAS VI Medulla oblongata VII Limbic system VIII Dopamine pathways IX Natural rewards X Addictive drugs Outline of Current Lecture I Addiction II Complexity of reward circuit III Reward circuit IV VTA V Drug memory VI Prefrontal cortex VII Tolerance These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute VIII Compulsive drug seeking behavior IX Craving and relapse Current Lecture Addiction o Condition that results when a person takes a drug or engages in an activity that is pleasurable o Repeated use of substance or activity becomes compulsive and interferes with responsibilities of routine life o Drug addiction Produces a powerful influence on the brain that is manifested in three distinct ways Craving for drug Loss of control over use of the drug Continuing use of drug despite known adverse consequences Complexity of the reward circuit o Human reward vs LA freeway system Reward circuit o Complex but contains a central link that plays a fundamental role o Link consists of the nerve connections between two particular small groups of neurons Ventral tegmental area VTA Nucleus accumbens VTA o Transmits this info to nucleus accumbens by releasing neurotransmitter dopamine from axons that innervate the nucleus accumbens o Activation of dopamine receptors in nucleus accumbens consistently associated with reward and pleasure Drug memory o Addictive drugs flood nucleus accumbens with dopamine o Hippocampus lays down memories of this rapid sense of pleasure satisfaction o Amygdala creates a conditioned response to certain stimuli Prefrontal cortex o Nucleus accumbens communicates with the prefrontal cortex which is involved in planning and executing tasks o Motivates the individual to actively seek out the drug Tolerance o Addictive drugs can release 2 10x

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