SC BIOL 302 - Protein Structures (2 pages)

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Protein Structures

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Protein Structures


Description of the different protein structures. How they interact is very important.

Lecture number:
Lecture Note
University Of South Carolina-Columbia
Biol 302 - Cell & Molecular Biology

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BIOL 302 1st Edition Lecture 5 Outline of Previous Lecture I Proteins II Nucleic Acids Outline of Current Lecture I Macromolecules a Protein Structures b Protein Domain Current Lecture I Protein Structures a Can form covalent bonds hydrogen ionic w R group Can change the pH and or the charge b Peptide Bond Interactions hydrogen connects to the oxygen due to hydrogen bonding In a stacking sheets coiling helix c Proline VS Valine i Proline causes the protein to bend secondary ii R group can rotate that s why its flexiable on Valine but on Proline it makes a ring which prevents rotation rigid and fixes the angle iii Valine is not secondary d Proteomics the study of proteins in fine details and bioinformatics helps i This helps determine the 3 D structure of the protein which forms primary sequences ii Very difficult iii IBM program machine that are super computers What makes models of the protein may look lie Computer is called Bluegene Q and there s 16 of them 1 Our Computer uses gigahertz 10 9 calculations per second 2 Teraflope 10 12 3 Petaflope 10 15 36 aa 3 months of processing time 20 computers e Linus Pauling i Chemist won 2 noble prizes 1951 chemistry These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute II ii 1930 he described what a chemical bond looks like He was political at 1960 a large nuclear pollution worked on antipoliferation and everyone thought he was a communist took his passport away iii Worked on two protein structures in his head 1 Alpha helix a Turns to the right b 3 6 proteins each turn c Stabilization is through the peptide bonds 2 Secondary structure a Held together by peptide bonds b Stacking found in lots of proteins iv Amphipathic alpha helix 1 Hydrophobic non polar 2 Hydrophilic polar CONTAINS BOTH 3 The top of the structure is always non polar through out and is going to be all the same sixe 4 2 can form a coiled coil where the non polar

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