PSIO 201 1st Edition Lecture 7 Outline of Last Lecture I. Cellular Level of Organization IV & V: The Nucleus and Regulation of Gene ExpressionOutline of Current Lecture II. Cellular Level of Organization: The Nucleus and Regulation of Gene ExpressionIII. Protein SynthesisA) TranscriptionB) TranslationCurrent LectureTranscription- Synthesis of RNA to DNA- Synthesis of a complimentary RNA strand using the base sequence of DNA as a template- Occurs in the Nucleus and RNA strand exits nucleus through nucleus pores- Contains both promoter and terminator on RNA strand- RNA Polymerase (enzyme) that makes the RNA chain out of DNA- Produces mRNA (alternative splicing of exons can produce distinct mRNA)Transcription Regulation- - Promoter Regulation is used as a mechanism for regulation of gene expression- Promotor- DNA sequence “upstream” to the start of the gene to which RNA polymerase binds- ‘Transcription factors’- proteins that bind to the promotor to augment binding of RNA polymeraseTranslation- RNA base sequence as a template for protein synthesis- Occurs in the cytoplasm- Involves mRNA, tRNA, and rRNA- Produces proteins when Ribosome is attached to RNA for protein synthesis- Ribosome reads the RNA and mRNA binds to small sub unitThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- Ribosome has two units- Small and Large with two sites – A to PA method of producing multiple proteins from a single RNA strand includes SPLICING. The Introns are folded and exons are sliced for multiple protein
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