UT Arlington BIOL 3322 - neurotransmitter (4 pages)

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neurotransmitters, electrical and chemical

Lecture number:
Lecture Note
University of Texas at Arlington
Biol 3322 - Brain and Behavior

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BIOL 3322 1nd Edition Lecture 6 I Chemical messages a Step 1 synthesis and storage i Synthesized in the axon terminal ii Synthesized in the cell body iii Synthesis some neurotransmitters are transported from the cell nucleus to the terminal button Others made from building blocks imported into the terminal are packaged into vesicles there iv Release in response to an action potential the transmitter is released across the membrane by exocytosis v Receptor action the transmitter crosses the synaptic cleft and binds to a receptor vi Inactivation the transmitter is either taken back into the terminal or inactivated in the synaptic cleft b Step 2 neurotransmitter release i Ca2 ii Calmodulin iii Action potential reaches the voltage sensitive terminal it opens calcium channels iv Incoming Ca2 ions bind to calmodulin forming a complex v Complex binds to vesicles releasing some from filaments and inducing others to bind to the presynaptic membrane and to emty their contents by exocytosis c Step 3 receptor site activation i Transmitter activated receptors ii Autoreceptors usually on cell body thermostat for the cell iii Quantum iv Dendrodendritic dendrites send messages to other dendrites v Axodendritic axon terminal of one neuron synapses on dendritic spine of another vi Axoextracellular terminal with no specific target Secretes transmitter into extracellular fluid vii Axosomatic axon terminal ends on cell body viii Axosynaptic axon terminal ends on another terminal ix Axoaxonic axon terminal ends on another axon d Step 4 deactivation of the neurotransmitter i Diffusion carries away from cell ii Degradation enzymatic degradation iii Reuptake transporter protein taken back into iv Glial cells transporter protein on neighboring glial cell v Know slide 12 II Varieties of neurotransmitters These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute a b c d About 50 different kinds have

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