Pitt BIOSC 1000 - Foundations of Biochemistry (10 pages)

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Foundations of Biochemistry



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Foundations of Biochemistry

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A brief overview of the chemical, cellular, genetic, evolutionary, and physical foundations of biochemistry.


Lecture number:
1
Pages:
10
Type:
Lecture Note
School:
University of Pittsburgh
Course:
Biosc 1000 - Biochemistry

Unformatted text preview:

BIOSC 1000 Lecture 1 Outline of Current Lecture 1 Introduction to the Course 2 Foundations of Biochemistry Current Lecture 1 Introduction to the Course Dr Craig Peebles A502A Langley Hall 412 624 4649 cpeebles pitt edu o 2 Office Hours 4 5pm Tues Thurs or by appointment TA Tushar Gupta o Office Hours 363 Crawford Hall o 11am 12pm Mondays o 2pm 4pm Thursdays Homework 130 points 3 exams 100 pts each Final 150 pts Foundations of Biochemistry Many scientific fields attribute to and overlap with biochemistry o Cell biology o Genetics o Chemistry o Physics o Evolution Some characteristics of Living Organisms o Highly complex structures with amazing microscopic organization o Extract usable energy from food or the environment to do mechanical and metabolic work o Defined and regulated functions o Responsive to environment o Reproduction like begets like o Evolves overtime Cellular Foundations o Three domains of Life Bacteria single celled Inhabit soils surface waters tissues of decaying living organisms Archaea single celled Extreme environments salt lakes hot springs acidic bogs ocean depths Eukarya o Evolved from Archaea Differences at the cellular level Bacterial and archaeal ribosomes are smaller than eukaryotic ribosomes but serve the same function of protein synthesis from an RNA message o Common structures of bacterial and archaeal cells Cells are 2 microns by 1 micron in size Nucleiod Pili Flagella Cell envelope Eukarya cells 5 100 microns nuclear envelope organelles Sources of Energy Phototrophs sunlight Chemotrophs oxidation of chemical fuels Further division Autotrophs directly from CO2 Heterotrophs require organic nutrients made by other organisms Examples Humans chemoheterotrophs Cyanobacteria photoautotrophs Chemical Foundations o Biomolecules achieve a high degree of variation while utilizing a modest number of low AMU elements Small atoms form stronger chemical bonds Most of the dry mass of any cell is composed of H C N O several other elements are used by



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