Slide 1 Microbial Diseases of the Skin and EyesLecture 23 ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ Slide 2 Biol 240 S06 2Learning Outcomes• Bacterial Infections of the Skin• Fungal Infections of the Skin• Viral Infections of the Skin• Infections of the Eyes ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________Slide 3 Biol 240 S06 3Skin• Stratum Corneum• Salt inhibits most microbes• Lysozymehydrolyzes peptidoglycan• Fatty acids inhibit some pathogens• DermcidinFigure 21.1 ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ Slide 4 Biol 240 S06 4• Gram-positive, salt-tolerant bacteria• Cocci–Staphylococcus epidermidis–Micrococcus luteus•Rods– Diphtheroids•Corynebacterium spNormal Microbiota of the SkinFigure 14.1a ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________Slide 5 Biol 240 S06 5• Exanthem– Skin rash arising from another focus of infection• Enanthem– Mucous membrane rash arising from another focus of infectionSkin Rashes ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ Slide 6 Biol 240 S06 6Skin LesionsFigure 21.2 ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________Slide 7 Biol 240 S06 7• Gram-positive cocci• Form biofilms•Staphylococcus epidermidis– catalase positive– coagulase-negative– Not normally a pathogen– Opportunistic in immumecompromised patients•Staphylococcus aureus– catalase positive– coagulase-positive– LeukocidinStaphylococcal Skin Infections