Pitt NUR 0012 - Plasma Membrane (4 pages)

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Plasma Membrane

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Plasma Membrane


Lecture number:
Lecture Note
University of Pittsburgh
Nur 0012 - Anatomy and Physiology I
Anatomy and Physiology I Documents

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Nur 0012 Lecture 6 Anatomy and Physiology 1 Outline of Last Lecture I Chapter 2 chemistry cont A Eicossanoid review B Proteins C Nucleic acids D ATP II Chapter 3 cells A Cell theory B Cell sizes C Cell membrane phospholipid bilayer Outline of Current Lecture I Plasma membrane fluid mosaic model A Integral proteins receptors enzymes channels CAMs B Peripheral proteins C Microvilli D Cilia II Membrane transport These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute A Interstitial space extracellular space intracellular space B Passive transport diffusion facilitated diffusion osmosis tonicity C Active transport Current Lecture I Plasma membrane changes rapidly to suit its needs fluid mosaic model not a static picture has hydrophilic and hydrophobic parts A Integral proteins has both hydrophobic and hydrophilic components allowing it to span entire membrane 1 Receptors bind to chemical messengers such as hormones sent from other cells has binding site specific to a messenger on extracellular portion a Membrane bound receptors bind to polar ligands molecules to start cascade of events inside cell very rapid only needs one ligand to complete process 1 Certain ligands and receptors have high affinity for each other 2 Receptor then undergoes conformational change changes shape 3 Releases energized G protein which runs across membrane until it binds with another protein 2nd messenger and activates it causing some sort of big metabolic response example cyclic AMP amplification cascade effect b Intracellular receptors found in cytoplasm or nucleus bind to nonpolar ligands steroid hormones result in formation of new proteins 1 Steroid binds to receptor then the complex binds to a DNAassociated receptor 2 DNA transcribed to mRNA then ribosomes help translate into a new protein 3 Somewhat slower but response is more long lasting 2 Enzymes breaks down chemical messengers and

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