Mizzou MICROB 3200 - Exam 1 Study Guide (22 pages)

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MICROB 3200 1nd Edition Exam 1 Study Guide Lectures 1 3 Lecture 1 August 26th 7 46 AM I What is microbiology The study of micro organisms including bacteria viruses fungi parasites which are of medical importance b Bacteria is highly adaptive Why important a Morbidity Mortality i 2nd leading cause of death worldwide 23 a Healthcare Associated Infections HAIs i Rapidly increasing cause of death in healthcare setting i Approximately 30 of hospital patients are on antibiotics at any one time a Antibiotic resistance i They ve evolved mechanisms to resist antibiotics making this more of a problem i Diseases we ve controlled may get to a point where we can t What information is important for you a Clinical setting i Information that you can use to diagnose and manage a patient with infectious disease a Research setting i Information that you can use to develop new therapies against infectious disease THINK LIKE A PHYSICIAN AND ASK 7 BASIC QUESTIONS a WHO is at risk a WHAT tests should be performed a WHERE is the organism prevalent body site and geographic area b WHEN is the isolation of the organism important a WHY is this organism able to cause disease a WHICH species are medically important a HOW is the disease managed and prevented a I I I Many pathogens aren t trying to cause disease A lot of issues are actually caused by our immune system trying to control it MICROBIAL PATHOGENESIS I I SYMBIOTIC RELATIONSHIPS BETWEEN MICROBES AND THEIR HOSTS a We host 100 million microorganisms b Mutualism I I I I I i Both species benefit from the association i EX Escherichia coli in human intestinal tract a Commensalism i One species benefits without harming the other ii EX Staphylococcus epidermidis on human skin a Parasitism i One species derives benefit while damaging its host i EX Mycobacterium tuberculosis human specific pathogen Normal Microbiota a Body is colonized by numerous mutualistic and commensal symbionts a Microbes that colonize the body s surfaces without normally