UMass Amherst KIN 470 - 2.4.14 kin 470 class notes (2 pages)

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2.4.14 kin 470 class notes



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2.4.14 kin 470 class notes

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Pages:
2
School:
University of Massachusetts Amherst
Course:
Kin 470 - Exercise Physiology

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2 4 14 kin 470 class notes Three pathways to generate ATP o Creatine kinase reaction o Glycolysis o Oxidative phosphorylation Three stages of oxidative phosphorylation o 1 Convert pyruvate to acetyl coa o 2 Combine with acetylacetate in process breaking down glucose harnessing energy from NADH FADH2 send through ETC make proton gradient substrates and how they might go into our glycolysis and Kreb s cycle o glucose o triglycerides fatty acids through beta oxidation o protein amino acids acetyl CoA2 o harness energy from FADH2 ETC o NADH o FADH2 o This is a complex chemical process o Essential thing flowing oxygen strong enough to power protons to move into mitochondrial space o Complex I III and IV o Flow of electrons pumps protons out this is useful because it creates a gradient Gradient energy that can be harnessed Ex pushing a ball uphill Point that allow it to occur ATP synthase Harnesses energy to create ATP Electron transport chain ETC moving e based on affinity o Cyanide works on cytochrome C stops that from accepting more electrons Might survive for a few mins but quickly cyanide will affect this protein in ETC no more energy for body ATP synthase o ATP it makes needs to get translocated out of their go to muscles There is apump that allows it to go out ADP to come in The Chemiosmotic Hypothesis of ATP Formation o Electron transport chain results in pumping of H ions across inner mitochondrial membrane Result in H gradient across membrane o Gradient provides energy to form ATP H drives the rotary motor ATPsynthase o Peter Mitchell and Paul Boyer How does ATPsynthase work o What will happen in the experiment o What key substrate is needed to make it happen o How can this happen without oxygen present o How is it different than what really happens in your mitochondria Few rotary motors in the body Answers o 1st question filament will rotate nd o 2 key substrate is ATP he was watching it break down ATP spnning in the opposite direction because it is changing



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