Victoria NewburyKin 110, Disc. Thursday 9:30Prof. BraunAnnotated BibliographyDue: 10.20.13Research Paper Topic: HealthHealth Gluten-free diets have become very popular and shelves of your favorite grocery store are dedicated to gluten-free products. The diet is intended to treat those with Celiac disease (a chronic immune reaction to gluten) or a gluten allergy. Many peoplebelieve that gluten is the cause of other health problems. The trending thought is that eliminating gluten from the diet would be beneficial for everyone, not just those with a documented medical condition. Describe the specifics of a gluten-free diet. Using evidence from scientific literature, what is the actual prevalence of “gluten-free dieters”? Why do people think gluten is the cause of health problems? Discuss the potential benefits and problems (e.g. nutrient deficiencies) with adopting a gluten-free diet on health (be sure to define what you mean by health; i.e. physical, mental, risk for disease etc..) Take a stand on the issue and conclude with your informed opinion regarding the likely effects of thediet on health in people who DO NOT have celiac disease or a gluten allergy. Peer reviewed sources:Buie, T. (2013). The relationship of autism and gluten. Clinical Therapeutics, 35(5), 578-583. doi: 10.1016/j.clinthera.2013.04.011***secondaryTennyson, C. A., Lewis, S. K., & Green, P. H. (2009). New and developing therapies for celiac disease. Therapeutic Advances in Gastroenterology, 2(5), 303-309. doi:10.1177/1756283X09342759***secondaryWeirdsma, N. J., van Bokhorst-de van der Schueren, M. A., Berkenpas, M., & van Bodegraven, A. A. (2013). Vitamin deficiencies and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients, 5(10), 3975-3992.***primaryWhite, L. E., Merrick, V. M., Bannerman, E., Russell, R. K., Basude, D., Henderson, P., … Gillett, R. L. (2013). The rising incidence of celiac disease in Scotland. Pediatrics, 132(4), 924-931.***primarySummary of sources:Points to touch upon:- What do they want to know? - What do they find out? - How do they find out?- How they help support the thesis statement?- Subject population- Methods used to do the study (experimental design)- Results from the study- What those results meanThesis Statement:Gluten free diets are not the best option for people who do not have celiac disease orgluten intolerance. This diet requires a lot of attention to what you are eating on a daily basis because gluten is often a main source of calories and has many of the daily nutrients your body requires. Gluten free diets are generally more expensive and therefore are inaccessible to some people. If you cannot afford the proper nutrients your body needs it is not recommended that you use this diet. People who are on a gluten-free diet often have deficiencies in several vitamins, calcium, iron, zinc, magnesium, and fiber (Wierdsma, van Bokhorst-de van der Schueren, Berkenpas, Mulder, & Bodegraven, 2013).Intro information Gluten free diets are becoming more prevalent as the incidence of celiac disease diagnosis increases. The increase in people being diagnosed may be due to improvedknowledge of the disease (White, Merrick, Bannerman, Russell, Basude, Henderson, … Gillett, 2013). Celiac disease has been associated with cases of autism, which is why it may be a major health problem. Because celiac disease prevents the break down of gluten, it leads to vitamin and mineral deficiencies (Wierdsma, van Bokhorst-de van der Schueren, Berkenpas, Mulder, & Bodegraven, 2013). Which is why a gluten free diets are very beneficial to people with celiac disease or gluten intolerance. Summary on “The Rising Incidence of Celiac Disease in Scotland”- Abstracto Increasing incidence of pediatric celiac disease Improved case ascertainment or true rise?o Aim: identify all incident cases of childhood CD Scotland 1990-2009 assess: trends in total incidence & cases diagnosed as a result of 1. Classic presentation, 2. Nonclassic, 3 targeted screening- what do these mean ^^^?o Methods 20 years case notes, pathology databases, endoscopy, patient records <16 years old at risk pop. : 225000-233000o results: 266 children increase in incidence from 1.8/100000 (1990-1994) to 11.7/100000 (2005-2009) nonclassic presentation & actively screened cases – increase by1566% and 1170%... ….o Conclusions Increased pediatric CD 6.4 –fold over 20 years rise is significant for classic CD indicates a true rise in the incidence of pediatric CDo background info: CD is…- Multisystem immunologic disorder- Before school age- Gastrointestinal symptoms Risk:- Family history- Type 1 diabetes mellitus- Extraintestinal symptoms- Prolonged fatigue Awareness of heterogeneity of CD- May affect incidence- Methodso Data collectedo Statistical analyses- Resultso Crude numbers diagnosedo Patient demographicso The incidence of pediatric CD in southeast Scotland is risingo All presentations of pediatric CD have risen in southeast Scotland Actively screened cases Nonclassic cases Classic casesThe importance was that it gives information about the prevalence of celiac disease and how diagnosis of the disease is increasing. As we gain knowledge about the disease, doctors are able to diagnose it much easier. It is common in people with diabetes and people who have a family history. This helps my article because it provides background information on celiac disease as well as it’s prevalence in othercountries. It supports my thesis statement because it talks about how gluten free diets lead to vitamin deficiencies.Summary on “vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients”- Malabsorption- Weight loss- Vitamin/mineral deficiencies- Assess:o Nutritional/vitamin mineral statue of current early diagnosed untreated adult CD patients in the Netherlands- Subjects:o Newly diagnosed patiends- Vitamin concentrationso Folic acid -20%o Vit A - 7.5%o Vit B6 - 14.5%o Vit b12 – 19%o Zinc – 67%o Haemoglobin o Ferritin- Anaemia- Iron deficiency- 17% malnourished- 22% women underweight- 29% patients overweight- conclusionso vitamin/mineral deficiencies not associated with a higher grade of histological intestinal damage or nutritional statuso still common in newly diagnosed patientso prevalence of obesity at initial diagnosis