BIOL 302 1st Edition Lecture 2Outline of Previous Lecture I. Experimental Model System Used for Studiesa. E. Colib. Yeastc. SV40 virusd. Dictyosteliume. Arabidopsisf. Drosophila (fruit fly)g. C. Elegansh. Zebra Fishi. Lab Mousej. Human CellsII. Culture Research TestingOutline of Current LectureI. Stem CellsII. Cell CycleCurrent LectureI. Stem Cellsa. Reach some kind of point and then die. Cancer cells grow in culture.b. The subset cells that are in the body give rise to mature cellsi. 200 different typesii. cancer cells are the type of cells that bypass the Hayflich limitc. Can be taken out and transferred that enables movement and suchd. Once it is taken out of culture and just to grow, it’s total potent. Don’t have an Hayflich limit and aren’t cancerous.e. Can grow into cells and then differentiated into nerve, blood cells, etc.f. Core blood (placenta & umbilical cord)i. contains a lot of stem cellsii. aren’t totipotentiii. similar to bone marrowg. iPS – induced potent stem cellsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.i. mature stem cells (fibroblast) and moving it back into differentiationII. Cell Cyclea. The Cycle:i. G0 phase: resting cell (non-dividing) – signal to divideii. G1 phase: ~10 hoursiii. S phase: DNA synthesisiv. Mitosis is something you can see if it replicates properlyb. P53: tumor suppressor genei. 80% - 90% of all cancers have a defect of the p53 genec. Dividing / cycling stem cell doesn’t enter G0 phase. Chemotherapy kills all dividing cellsd. Non-dividing / resting – immune system, skin, livere. Permanent non-diving – many cells of CNSf. Apoptotic – cell
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