University of Minnesota College of Pharmacy PHAR 6124 Pharmacotherapy IV Patient-Centered Pathophysiologic Approach Mark Kirstein, Pharm.D. Course Director Spring 20092 PHARMACOTHERAPY IV: Patient-Centered Pathophysiologic Approach Section Directors: Infectious Diseases: John C. Rotschafer, Pharm.D. Office: 612-624-2183 [email protected] Oncology: Mark Kirstein, Pharm.D. Office: 612-624-5689 [email protected] Toxicology: Leo Sioris, Pharm.D. Office: 952-852-4604 [email protected] Pharmacotherapy IV – SPRING 2008 Patient-Centered Pathophysiologic Approach MoosT 1-450 T, Th – 10:10-12:05 Friday – 9:05 – 9:553 This course serves as an introduction to the pathophysiology and pharmacology of infectious diseases, oncologic, and toxicologic disorders. MEETING PLACE AND TIME Lectures for this course will be held in MoosT 1-450. Tuesday, Thursday 10:10-12:05 and Friday 9:05-9:55 Infectious Diseases Schedule 2009 INFECTIOUS DISEASES SCHEDULE Day (Date) Time Topic, Readings Lecturer Tuesday (1/20/09) 10:10-12:05 INTRODUCTION/PHARMACODYNAMICS J. Rotschafer Thursday (1/22/09) 10:10-11:00 BACTERIOLOGY M. Ullman 11:15-12:05 BACTERIAL RESISTANCE I A. Noreddin Friday (1/23/09) 09:05-09:55 BACTERIAL RESISTANCE II J. Rotschafer Tuesday (1/27/09) 10:10-11:00 AMINOGLYCOSIDE MONITORING J. Rotschafer 11:15-12:05 SINGLE DAILY DOSE AMINOGLYCOSIDES J. Rotschafer 12:00-12:00 ONLINE QUIZ Thursday (1/29/09) 10:10-11:00 AMINOGLYCOSIDE PROBLEM SETS M. Ullman 11:15-12:05 VANCOMYCIN J. Rotschafer 12:00-12:00 1st AMINOGLYCOSIDE PHARMACOKINETICS QUIZ Friday (1/30/09) 09:05-09:55 FLUOROQUINOLONES A. Noreddin Tuesday (2/3/09) 10:10-11:00 ANTIFUNGALS M. Ullman 11:15-12:05 URINARY TRACT INFECTIONS J. Rotschafer 12:00-12:00 ONLINE QUIZ Thursday (2/5/09) 10:10-11:00 VACCINES M. Ullman 11:15-12:05 MENINGITIS J. Rotschafer 12:00-12:00 2ND AMINOGLYCOSIDE PHARMACOKINETICS QUIZ Friday (2/6/09) 09:05-09:55 TUBERCULOSIS A. Noreddin Tuesday (2/10/09) 10:10-11:00 HIV-1 H. Vezina 11:15-12:05 HIV-II H. Vezina4 12:00-12:00 ONLINE QUIZ Thursday (2/12/09) 10:10-11:00 SEXUALLY TRANSMITTED DISEASES M. Peterson 11:15-12:05 HIV-III H. Vezina 12:00-12:00 3rd AMINOGLYCOSIDE PHARMACOKINETICS QUIZ Friday (2/13/09) 09:05-09:55 VIRAL INFECTIONS H. Vezina Tuesday (2/17/09) 10:10-11:00 OPPORTUNISTIC INFECTIONS M. Ullman 11:15-12:05 SKIN AND SOFT TISSUE INFECTIONS M. Peterson 12:00-12:00 ONLINE QUIZ Thursday (2/19/09) 10:10-11:00 PNEUMONIA J. Rotschafer 11:15-12:05 OSTEOMYELITIS M. Peterson Friday (2/20/09) 09:05-09:55 ENDOCARDITIS J. Rotschafer Tuesday (2/24/09) 10:10-11:00 INTRA-ABDOMINAL INFECTIONS M. Peterson 11:15-12:05 BIOTERRORISM J. Rotschafer Thursday (2/26/09) 10:10-11:00 PARASITIC INFECTIONS M. Ullman 11:15-12:05 REVIEW M. Ullman Friday (2/27/09) 09:05-09:55 TOXICOLOGY THROUGH THE AGES Filandrinos Tuesday (3/3/09) 10:10-12:05 FINAL EXAM5 TOXICOLOGY SCHEDULE 2009 DAY (DATE) TIME TOPIC LECTURER Friday (2/27/09) 9:05-9:55 Toxicology Through the Ages Filandrinos Tuesday (3/3/09) 10:10-11:00 Infectious Diseases Final Exam Rotschafer 11:15-12:05 Infectious Diseases Final Exam Rotschafer Thurs. (3/5/09) 10:10-11:00 General Management and Gastric Decontamination Filandrinos 11:15-12:05 Laboratory Evaluation of the Poisoned Patient Sioris Friday (3/6/09) 9:05-9:55 Drugs of Abuse (Stimulants) Case Study Gualtieri Tuesday (3/10/09) 10:10-11:00 Drugs of Abuse (Opiates, hallucinogens, GHB, inhalant abuse) Gualtieri 11:15-12:05 Sedative Hypnotics/Alcohol Withdrawal Gualtieri Thursday (3/12/09) 10:10-11:00 Acetaminophen Toxicity Case Study Filandrinos 11:15-12:05 Snakes and Spiders Keyler Friday (3/13/09) 9:05-9:55 Mid-Term Sioris Tuesday (3/17/09) 10:10-11:00 SPRING BREAK 11:15-12:05 SPRING BREAK Thursday (3/19/09) 10:10-11:00 SPRING BREAK 11:15-12:05 SPRING BREAK Friday (3/20/09) 9:05-9:55 SPRING BREAK Tuesday (3/24/09) 10:10-11:00 Calcium Channel Blockers/Beta Blockers Case Study LeMaster 11:15-12:05 OTC Drug Products/Vitamins/Dietary Supplements K. Sioris Thursday (3/26/09) 10:10-11:00 Salicylates/Non-Steroidals Case Study Kingston 11:15-12:05 Toxicology Potpourri LeMaster Friday (3/27/09) 9:05-9:55 Antidepressants Case Study Gualtieri Tuesday (3/31/09) 10:10-11:00 Ethylene Glycol/Methanol Case Study Filandrinos 11:15-12:05 Household Products & Carbon Monoxide Case Study Sioris Thursday (4/2/09) 10:10-11:00 Alcohol & Forensic Toxicology Sioris 11:15-12:05 Pesticides (Organophosphates & Pyrethrins) Case Study K. Sioris Tuesday (4/7/09) 10:10-11:00 Toxicology Final Sioris6 COURSE OBJECTIVES Infectious Diseases The infectious diseases section of the course relates to pharmacotherapeutics and treatment of infectious diseases and aims to integrate material from MedC 6156, and other courses, with infectious disease topics important to the clinical setting. Ideally, at the end of this course the student will be able to: identify likely pathogens responsible for a particular infectious disease process; select the appropriate antibiotic(s) to provide antimicrobial coverage for these possible pathogens; select alternative antibiotics should they become necessary; and identify appropriate actions to monitor for efficacy and toxicity. To accomplish these goals, the student will be required to comprehend common microbiologic laboratory tests used to identify microorganisms. The student will be expected to know the mechanisms of action, antimicrobial spectrum, mechanisms of bacterial resistance, common adverse reactions, pharmacokinetics, and appropriate dosing of the various antibiotics discussed in the upcoming lectures. The students Oncology Schedule Date Topic Lecturer Friday 4/3/09 Introduction to Oncology Jacobson Tuesday 4/7/09 Toxicology Exam Sioris Tuesday 4/7/09 Introduction to Oncology Jacobson Thursday 4/9/09 Chemotherapeutic agents Kirstein Thursday 4/9/09 Chemotherapeutic agents Kirstein Friday 4/10/09 Antiemetics Whalen/Lohr Tuesday 4/14/09 Antiemetics Whalen/Lohr Tuesday 4/14/09 Colorectal Cancer/Pancreatic Cancer Kirstein Thursday 4/16/09 Quiz; Prostate Cancer/Renal Cell Kirstein Thursday 4/16/09 Oncology Complications Lohr Friday 4/17/09 Oncology Complications Lohr Tuesday 4/21/09 Fever and Neutropenia Jacobson Tuesday 4/21/09 Breast Cancer Fahrenbruch Thursday 4/23/09 Breast Cancer Fahrenbruch Thursday 4/23/09 Lung Cancer Kirstein Friday 4/24/09 Exam through Fever and Neutropenia Kirstein