BIMM118 – Midterm ’07NOTE: WRONG answers on multiple choice questions will result in the DEDUCTION of the points !!!!!1) When a loading dose is administered, the initial drug concentration is dependent on which of the following:a) elimination rate constantb) drug half-lifec) volume of distributiond) clearance e) metabolismf) amount of drug administered(5 pts each)2) Which of the following drugs would be useful in treating malathione poisoning:a) Dobutamineb) Epinephrinec) Atropined) Propranolole) Succinylcholine(5 pts each)3) An older man is admitted to the emergency room with severe hypotonic crisis. In his pocket the staff finds a vial of Viagra, and, upon further examination, they notice a transdermal delivery system (“patch”) on his chest. What is likely to have caused the symptoms? Justify your conclusion!(15 pts)4) Provide an example for altered drug responses based on pharmacogenetics! (15 pts)5) What was the goal of the Orphan Drug Act of 1983? (10 pts)6) To which category do beta-1 receptor blockers as antihypertensive drugs belong?a) Palliativeb) Therapeuticc) Prophylacticd) None of the above(5 pts each)7) Describe three different extended drug delivery systems! (5 pts each)8) Which of the following options is the best scenario for a sun lotion (drug=UV absorber)? a) Lipophilic drug in lipophilic baseb) Hydrophilic drug in lipophilic basec) Lipophilic drug in hydrophilic based) Hydrophilic drug in hydrophilic base(5 pts each)9) What is bioavailibility?(10 pts)10) What is the “loading dose”? Describe its goal, and what parameters it is dependent on?(5 pts each)11) Why do amphetamines produce more pronounced norepinephrine-baased physiological reactions than MAO inhibitors?(15 pts)12) Which of the following modifications are NOT considered Phase II reactions a) Glucuronidationb) Alkylationc) Sulfationd) Glutathione conjugatione) Dehalogenation(5 pts each)13) Which of the following drugs can be used to treat glaucoma?a) Pilocarpineb) Propranololc) Losartand) Physiostigminee) Atropine(5 pts each)14) Prazosin is more effective as an antihypertensive drug than phentolamine – explain why?(15
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