shared via CourseHero com This study resource was This study source was downloaded by 100000834183074 from CourseHero com on 11 04 2021 10 57 57 GMT 05 00 https www coursehero com file 36070880 Tymo TB ch 17doc Chapter 17 GluconeogenesisMatching QuestionsUse the following to answer questions 1 10 Choose the correct answer from the list below Not all of the answers will be used a liverb musclec one dayd endoplasmic reticulume gluconeogenesisf phosphoenolpyruvate carboxykinaseg PFK 2h Corii fructose 2 6 bisphosphatej magnesium k oxaloacetatel biotinm 2 hoursn ATP1 This is the process by which noncarbohydrate precursor molecules are convertedinto glucose Ans eSection Introduction2The stores of glucose are enough to support metabolism of a person for how long Ans cSection Introduction3The major tissue in which gluconeogenesis takes place is Ans aSection Introduction4 The conversion of glucose 6 phosphate to glucose takes place where in the cell Ans dSection 17 15The reaction that uses GTP and not ATP as its high phosphoryl transfer potential donor is Ans fSection 17 1 shared via CourseHero com This study resource was This study source was downloaded by 100000834183074 from CourseHero com on 11 04 2021 10 57 57 GMT 05 00 https www coursehero com file 36070880 Tymo TB ch 17doc Chapter 17 Gluconeogenesis6Which compound will activate glycolysis and inhibit gluconeogenesis via conversion of fructose1 6 bisphosphate Ans iSection 17 27 controls the synthesis and degradation of fructose 2 6 bisphosphate Ans gSection 17 28 This intermediate is decarboxylated and phosphorylated to produce phosphoenolpyruvate Ans kSection 17 19 This essential nutrient is required for the carboxylation of pyruvate in humans Ans lSection 17 110The cycle is responsible for converting muscle lactate into glucose in the liver Ans hSection 17 3Fill in the Blank Questions11 The daily glucose requirement for a typical adult brain is Ans 120 g Section Introduction12 The amount of glucose in the bloodstream and other body fluids is Ans 20 g Section Introduction13 The process of forming glucose from amino acids is called Ans gluconeogenesis Section 17 114 Glycerol from fats is modified first by glycerol kinase and then by a second enzyme to enter gluconeogenesis at intermediate Ans dihydroxyacetone phophate Section 17 115 The gluconeogenesis step responsible for reversing pyruvate kinase is Ans PEPCK Section 17 116 Gluconeogenesis is the reversal of steps in glycolysis true or false Ans false Section 17 12 shared via CourseHero com This study resource was This study source was downloaded by 100000834183074 from CourseHero com on 11 04 2021 10 57 57 GMT 05 00 https www coursehero com file 36070880 Tymo TB ch 17doc Chapter 17 Gluconeogenesis17 Some amino acids are converted to glucose via conversion to pyruvate and Ans oxaloacetate Section 17 118 The enzyme that carboxylates pyruvate is Ans pyruvate carboxylate Section 17 119The first step of gluconeogenesis takes place in cellular compartment Ans mitochondria Section 17 120 ATP in the reaction catalyzed by PEPCK is use to fix to biotin Ans carbon dioxide Section 17 121 Transport of oxaloacetate produced by PEPCK utilizes mitochondrial and cytosolic enzyme Ans Malate dehydrogenase Section 17 122 AMP will have a an on PFK and a an effect on F 1 6 BPase Ans activating inhibiting Section 17 223 Allosteric activators of gluconeogenesis are going to the flux of carbon to glucose Ans increase Section 17 224The cycle refers to the metabolic reactions by which glucose is converted into lactate in skeletal muscle and then lactate converted back into glucose in the liver Ans Cori Section 17 325The first step in gluconeogenesis is the of pyruvate to form oxaloacetate Ans carboxylation Section 17 1Multiple Choice Questions26 Biotin provides for the pyruvate carboxylase reaction A a long flexible arm for active site location of substrateB carboxylation of pyruvateC group transfer from one site of the enzyme to anotherD All of the above E None of the above Ans D Section 17 127 The phosphoryl donor in the formation of phophoenolpyruvate is A pyruvate B PEP C ATP D GTP E inorganic phosphate Ans D Section 17 128 The enzymes involved in shuttling carbons in gluconeogenesis from the mitochondria to the cytosol are called A malate dehydrogenase 3 shared via CourseHero com This study resource was This study source was downloaded by 100000834183074 from CourseHero com on 11 04 2021 10 57 57 GMT 05 00 https www coursehero com file 36070880 Tymo TB ch 17doc Chapter 17 GluconeogenesisB citrate synthase C oxaloacetate transferase D oxaloacetate reductase E None of the above Ans A Section 17 129 Glucose 6 phosphatase takes place in which cellular location A cytoplasmB endoplasmic reticulumC mitochondriaD nucleusE plasma membraneAns B Section 17 130 High levels of ATP and citrate A indicate a high energy well fed stateB indicate remote gluconeogenesisC inhibit glycolysisD All of the above E None of the above Ans D Section 17 231 Phosphofructokinase PFK is a highly regulated enzyme Which of the following statements about PFK are correct A AMP and ADP both bind to and stabilize the inactive conformation of F6P B ATP can overcome the inhibition by citrate C Citrate is an inhibitor of PFK D Acidic conditions from anaerobic metabolism activate PFK E None of the above Ans E Section 17 232 The bifunctional enzyme is also known as A phosphofructokinase IB phosphofructokinase IIC fructose 1 6 phosphataseD protein kinase 2E phosphoenolpyruvate carboxy kinaseAns B Section 17 233 Hormonal activation of cyclic AMP levels will A activate protein kinase A phosphorylation of FBPase2 B phosphorylate PFK2 on a tyrosine residue C lead to the activation of PFK D activate the PKC phosphorylation of PFK2 E increase the activation of gluconeogenesis Ans E Section 17 24 shared via CourseHero com This study resource was This study source was downloaded by 100000834183074 from CourseHero com on 11 04 2021 10 57 57 GMT 05 00 https www coursehero com file 36070880 Tymo TB ch 17doc Chapter 17 Gluconeogenesis34 The major site for gluconeogenesis is in which of the following tissues A brainB liverC striated muscleD adiposeE red blood cellsAns B Section Introduction35 High blood sugar after a meal the level of insulin released by the pancreasA increasesB decreasesC has no effect onD chronically activatesE chronically inhibitsAns A Section 17 236 In general the liver A will not utilize glucose under starvation low energy conditions