Autonomic Nervous System Pharmacology Study Guide Sympathomimetics Adrenergic Agonists Non Selective Agonists Epinephrine Mechanism of Action Binds to and adrenergic receptors Uses Anaphylaxis cardiac arrest asthma Side Effects Hypertension arrhythmias anxiety Selective Agonists Phenylephrine Selective Agonists Albuterol Mixed and Agonists Isoproterenol Mechanism of Action Selective 1 receptor agonist Uses Nasal decongestion hypotension Side Effects Hypertension reflex bradycardia Mechanism of Action Selective 2 receptor agonist Uses Asthma bronchospasm Side Effects Tremor tachycardia Mechanism of Action Non selective agonist Uses Bradycardia heart block Side Effects Tachycardia arrhythmias Sympatholytics Adrenergic Antagonists Blockers Prazosin Mechanism of Action Selective 1 receptor antagonist Uses Hypertension benign prostatic hyperplasia Side Effects Orthostatic hypotension dizziness Non Selective Blockers Propranolol Cardioselective 1 Blockers Metoprolol and Blockers Carvedilol Mechanism of Action Non selective receptor antagonist Uses Hypertension angina migraine prophylaxis Side Effects Bradycardia bronchoconstriction Mechanism of Action Selective 1 receptor antagonist Uses Hypertension angina heart failure Side Effects Fatigue bradycardia Mechanism of Action Non selective and receptor antagonist Uses Heart failure hypertension Side Effects Hypotension dizziness Parasympathomimetics Cholinergic Agonists Direct Acting Agonists Bethanechol Mechanism of Action Stimulates muscarinic receptors Uses Postoperative urinary retention Side Effects Bradycardia hypotension Indirect Acting Agonists Acetylcholinesterase Inhibitors Donepezil Mechanism of Action Increases acetylcholine levels in the brain Uses Alzheimer s disease Side Effects Nausea diarrhea Parasympatholytics Anticholinergic Agents Muscarinic Receptor Antagonists Atropine Mechanism of Action Blocks muscarinic receptors Uses Bradycardia organophosphate poisoning Side Effects Dry mouth blurred vision constipation Antimuscarinic for COPD Ipratropium Mechanism of Action Blocks muscarinic receptors Uses COPD asthma Side Effects Dry mouth blurred vision Antimuscarinic for Overactive Bladder Oxybutynin Mechanism of Action Blocks muscarinic receptors Uses Overactive bladder Side Effects Dry mouth constipation Adrenergic Neuron Blockers Guanethidine Mechanism of Action Prevents norepinephrine release Uses Hypertension Side Effects Orthostatic hypotension diarrhea