Instructors Lecture Labs Grading Teaching Assistants Note any student in any section can attend any office hours NPB 100L Neurobiology Laboratory Mark Goldman Center for Neuroscience 1544 Newton Court Phone x7 8749 Email msgoldman ucdavis edu Office Hrs Tuesdays 12 1 30pm SciLab 2012 or by appointment Natalia Caporale 188A Briggs Hall Phone x2 8976 Email ncaporale ucdavis edu Office Hrs Tuesdays 9 30 10 50am SciLab 2012 or by appointment Dovin Kiernan Email dkiernan ucdavis edu Office Hrs Mondays 2 3 30pm SciLab 2012 or by appointment Bryan Le Email bynle ucdavis edu Office Hrs Wednesdays 4 5 30pm SciLab 2012 or by appointment Tuesdays 11 00 11 50am Wellman 212 section 1 Thursdays 10 00am 12 50pm SciLab 2012 section 2 Thursdays 1 40pm 4 30pm SciLab 2012 Pre lab assignments Lab attendance Lab reports Final projects 15 5 40 40 Project proposals due Sunday Nov 6 at 11 59pm Final projects due Friday Dec 9 at 4 30pm Texts Other references on reserve NEURON documentation available at http www neuron yale edu neuron Nicholls From Neuron to Brain 5th edition Purves Neuroscience 5th edition Luck An Introduction to the Event Related Potential Kramer Eden Case Studies in Neural Data Analysis Stanford MathTools for Neuroscience math primer on Canvas Homework Policy Guide You are encouraged to work together and help each other by discussing pre laboratory assignments and post laboratory data analysis However your final pre laboratory assignments post laboratory reports and final projects must be written up individually and handed in separately to your TA In all cases students must abide by the UC Davis Student Code of Conduct http sja ucdavis edu files cac pdf Policy on Late Assignments Excused extensions on assigned work will be given only for significant illness or family crisis If an excused extension or postponement is requested you You will be allowed 3 free days of unexcused extensions on homework assignments must notify your TA or the course instructor prior to the class period before which the work is due Sundays will not count as a day to flexibly manage scheduling difficulties across the quarter Once these free days have been used late work will be penalized at 20 per day TENTATIVE CLASS SCHEDULE SUBJECT TO CHANGE Labs are italicized Date Sept 22 Thurs SLB 2012 Topics Lab Introduction Measuring Electrical Signals Introduction to experimental design Sept 27 Tues Wellman 212 Course Introduction Characterizing sensory responses Quantifying stimulus response correlation Sept 29 Thu SLB 2012 Neurophysiology 1 Sensory coding Mapping the sensory responses of cockroaches with single neuron recordings of action potentials Oct 4 Tues Wellman 212 Introduction to electrophysiological recording Introduction to the crayfish CNS Oct 6 Thu SLB 2012 Neurophysiology 2 Motor nerve responses Multi neuron recordings of action potentials from the crayfish CNS Oct 11 Tues Wellman 212 Oct 13 Thu SLB 2012 Oct 18 Tues Wellman 212 Oct 20 Thu SLB 2012 Electrical properties of neurons Nernst potentials currents conductances capacitance Introduction to the action potential Neuronal biophysics 1 Ionic basis of the resting potential Electrical circuit model of a neuron Introduction to NEURON simulator part 1 Action potential propagation Axons dendrites and myelin Reflex circuits of the brain Introduction to NEURON part 2 Neuronal biophysics 2 Action potential propagation Measuring modeling a human reflex Homework Postlab 0 assigned see Canvas due Tuesday Sept 27 at 11 59pm Prelab 1 assigned see Canvas hardcopy due at start of your lab section Postlab 1 assigned see Canvas due Tuesday Oct 4 at 11 59pm Prelab 2 assigned due in lab at start of lab Postlab 2 assigned Prelab 3 assigned Postlab 3 assigned Prelab 4 assigned Postlab 4 assigned Oct 25 Tues Wellman 212 Motor control and perception Motor systems and feedback Threshold psychophysics Multisensory integration Prelab 5 assigned Oct 27 Thu SLB 2012 Higher cognition 1 Motor control and perception Motor and perceptual estimates of object weight Postlab 5 assigned Nov 1 Tues Wellman 212 Cognitive neuroscience Introduction to EEG event related potentials Rhythms of the brain Introduction to Fourier Analysis Higher cognition 2 Human Perception Measuring analyzing correlates of conscious perception using scalp EEG Project planning proposal feedback session Nov 3 Thu SLB 2012 Nov 8 Tues Wellman 212 Nov 10 Thu SLB 2012 Nov 15 Tues Wellman 212 Nov 17 Thu SLB 2012 Nov 22 Tues Wellman 212 Nov 24 Thu Nov 29 Tues Wellman 212 Dec 1 Thu SLB 2012 Perform project experiment 1 Project feedback session 1 Perform project experiment 2 Project feedback session 2 No lab Thanksgiving holiday Project presentation Q A discussion Lab group time to work on presentations Prelab 6 assigned Develop project proposal due Sunday Nov 6 at 11 59pm Prelab 7 assigned Write progress report plans for session 2 due Sunday Nov 13 at 11 59pm Analyze data in preparation for project presentation due Sunday Nov 20 at 11 59pm Class conference project presentations Final project paper due Dec 9 at 4 30pm Reference Reading by Module 1 2 Neurophysiology labs posted in NichollsMatthewsPurves ElectrophysRecording SensoryResponses pdf For both labs 1 2 Recording neuronal activity Nicholls Chpt 1 pp 10 11 Signaling in Nerve Cells section intro through Techniques for Recording Signals from Neurons with Electrodes For lab 1 Sensory systems overview Matthews Neurobiology 2nd ed pp 282 287 read through 1st paragraph of The receptive field of primary receptor neurons p 295 Adaptation section Purves et al Neuroscience 3rd ed p 195 example sensory system recording 3 4 Neuronal biophysics labs Lab 3 Resting potentials and electrical circuit model Nicholls Chpt 4 pp 70 73 Measurement of Single Channel Currents section from Channel Conductance through The Nernst Equation and Chpt 6 pp 100 108 from A Model Cell section through An Electrical Model of the Membrane These are posted in Nicholls Biophysics pdf Voltage Current Resistance Capacitance RC circuits See the posted CircuitPrimer or if you have taken Physics review your physics notes on electrical circuit concepts voltage current resistance capacitance Kirchoff s laws parallel and series resistors RC circuits Review your notes from NPB 100 or 110B on electrical circuit concepts Simple differential equations Review your Math 17 21 notes or see Stanford MathTools Reader Chpt 3 pp 8 16 Lab 3 postlab NEURON model posted in Nicholls Biophysics pdf Action potential generation