PSIO 431 Assignment 4 Can you think of conditions where switching a patient s response from Th1 to Tfh dominated or vice versa might be helpful Th1 cells secrete the lymphokine interferon gamma which is pro inflammatory and chemotactic for monocytes in the blood that become tissue macrophages Tfh cells help B cells that have recognized antigen to become activated and differentiate into plasma cells that secrete antibody Tfh secretes cytokines which allows for B cells to class switch which antibody they secrete A condition where switching a patient s response from Th1 to Tfh would be helpful in conditions where the patient has problems with chronic inflammation or diseases associated with too much inflammation On the other hand switching a patient s response from Tfh to Th1 could be helpful in cases where a person would want an intense inflammatory response and a more aggressive immune response such as a severe bacterial infection Citations Cohen Z Fall 2015 T cells In Immunology