Chapter 26 Review the names and structures of nucleotides and nucleic acids Know the source of carbon and nitrogen atoms of the purine ring Know the names and functions of the enzymes required for IMP synthesis and the cofactors required Describe the synthesis steps of IMP synthesis know the activation step and the committed step of synthesis Know how azaserine inhibits IMP synthesis and how folate analogs used as antimicrobial and anticancer agents Know the general steps of GMP and AMP synthesis from IMP Describe how purine are salvaged and the enzymes involved Know the steps of purine degradation and the products they yield Describe the synthesis steps of pyrimidine know the committed step of synthesis know the difference between CPS I and CPS II Know that UMP is synthesized rst and how its synthesis leads to synthesis of UTP CTP Know the products of pyrmidine degradation Know the chemical steps required to prepare deoxyribonucleotides for DNA synthesis Know the path of thymine nucleotide synthesis from dUMP know how uoro substituted analogs used as therapeutic agents