Elements of a eukaryotic gene are more or less exposed based on chromatic remodeling Initiation of transcription requires multiple factors coming together cid 127 Many regulatory regions can play a role in the control of transcription or initiation In eukaryotes one gene has exactly one transcript Promoter proximal and distal elements are recognized and linked by regulatory proteins The input of multiple transcription regulators are integrated at the basal transcription complex and determine if transcription proceeds cid 127 Gene expression can be regulated after transcription by changing the ways that exams are spliced together Tropomyodin is expressed in both skeletal and smooth muscles It codes for two different proteins based on alternative splicing of exons cid 127 mRNA stability can be influenced by microRNAs that target it for degradation Hairpin folding is a result of complementary base baiting cid 127 miRNA acts as a specific signal for RISC protein that breaks down mRNA specificity is by complementary base pairing Cancer is not a single disease Suite of diseases caused by similar cellular problems Two commons causes of uncontrolled cell growth Tumor suppressor genes stop or slow cell cycle Proto oncogenes speed up cell growth cid 127 cid 127 cid 127 cid 127 cid 127 cid 127 cid 127 cid 127 cid 127 cid 127 cid 127 cid 127 cid 127
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