PRINT your name please Practice Questions for Exam 3 Note These questions are to be divided between the two groups in each Discussion section who are to present Exam 3 answers Since Exam 3 has different material that was divided among other exams in previous semesters I selected many old favorites from other years to challenge you The questions should be divided so both groups have the same amount of content to prepare and present I would not recommend one group do 1 through 7 while the other do 8 through 14 Dr Harley Schmedlap Jr noted physiologist and part time three star chef at the South 1 Campus Dining Hall has made a remarkable discovery He has captured a ferocious and voracious little creature lurking about in the vegetable bins of the kitchen Schmedlap has ascertained that this creature used to inhabit the Stamp Union feeding on Krispy Kremes Displaced by the renovations in progress this beast is now forced to forage for healthy foods and is rapidly wasting away from lack of grease and calories In an effort to acquire information required to preserve the species which he aptly named Krispus kremius higginsonii Schmedlap has gathered the following physiological data Substance D Substance Q 0 48 0 24 0 06 1 2 0 6 0 6 0 0 2 4 PA mg 100 ml plasma PV in renal vein mg 100 ml plasma Urine mg ml urine Amount of substance originally injected mg Rate or urine formation 0 5 ml min Clearance of Inulin 3 mls min Hematocrit 0 40 Heart Rate 120 beats min Blood ejected per beat 4 mls Respiratory Tidal volume 4 0 mls Respiratory Rate 24 breaths min Conducting airway volume 1 2 ml BP 180 120 mm Hg Use the data above and answer the following You MUST include UNITS where appropriate 1 a b c d e f g h i j k l n o 2 a Renal BLOOD Flow a 21 ml min PRINT your name please Filtration Fraction b 0 24 Glomerular Filtration Rate c 3 ml min Rate of water reabsorption by the kidney d 2 5 ml min Extraction ratio of Substance Q e 0 Cardiac Output f 480 ml min Alveolar Ventilation Rate g 67 ml min Mean Arterial Blood pressure MAP h 140 mmHg Rate at which D is put into glomerular filtrate i 0 0144 mg min What does the kidney do with Substance D j filter and secrete At what rate is D reabsorbed or secreted k 0 0156 mg min Rate at which D is put into urine l 0 03 mg min m What are two alternative but reasonable assumptions about what happens to Substance Q in the nephrons 1 Substance Q is filtered and reabsorbed 2 Substance Q is too large to pass through could be a protein Use one of your assumptions from part m above and calculate the animal s PLASMA volume n 400mL Now use your other assumption for substance Q At what rate is Q reabsorbed o 1 8 mg min Aldosterone secretion results in increased blood volume List two different stimuli or signal molecules that initiate aldosterone secretion you may NOT list decreased blood volume or atrial EDV 2 PRINT your name please 1 Renin What is the specific molecular result of aldosterone on the cells of the kidney tubules 2 Na Cl levels 3 High K b Aldosterone inserts Na K pumps into the basolateral membrane of kidney tubules and K channels This causes reabsorption of Na and secretion of K 3 for 2 respectively This increases the osmotic pressure inside the capillaries as more Na enters This increase in osmolarity causes water to follow Chloride also follows c What are the effects of aldosterone on ion reabsorption secretion Which ions Increases reabsorption of Na causes secretion of K Explain how this action increases blood volume d 3 Na enter the peritubular fluid capillary and 2 K exit so peritubular fluid has higher increase in ion concentration and thus a higher osmotic pressure Water will thus follow Na through aquaporins Five 5 mg of each of the following substances was injected i v into a small 30 Kg mammal DATA for Question 3 Substance 1 PA in mg 100 ml 0 005 PV in mg 100 ml 0 0025 U in mg ml V in ml min substance in Glom Filtrate in mg 100 ml 0 05 0 1 0 005 Filtration Fraction 0 25 Hct 0 47 HR 180 beats min Resp Rate 26 breaths min plasma 19 6 mEq L HCO3 Substance 2 0 009 0 008 0 02 0 1 0 009 Substance 3 0 008 0 006 0 04 0 1 0 008 Substance 4 0 010 0 010 0 0 0 1 0 0 SV 0 6 ml beat Tidal Volume 0 6 ml Conducting Respiratory airway vol 0 2 ml Arterial plasma pH 7 56 3 PRINT your name please Using the data on the last page please answer the following questions You must include 3 all units where required a Renal Blood Flow is 377 ml min b GFR is 50 ml min c Which substance is filtered and secreted Substance 1 d At what rate is this substance placed into the filtrate in Bowman s Capsule 0 0025 mg min e At what rate is this substance placed into the urine 0 005 mg min f At what rare is this substance secreted 0 0025 mg min g What is the clearance of Substance 4 0 mg min h What is the rate of water reabsorption 49 9 ml min i Which substance could be inulin Substance 3 j What is the alveolar ventilation rate 10 ml min k What is the BLOOD VOLUME 94340 ml l What appears to be the specific problem NAME the condition with this creature s pH pH to high respiratory alkalosis m What could cause this condition Hypoventilation n What is the body s immediate response to correct it What initiates this regulatory process How is it controlled 4 PRINT your name please The body will secrete less H in the kidneys and reabsorb less bicarb as well PCO2 less than 40 mm Hg causes it Please accurately draw draw a nice big cell for ease of interpretation a cell of the PCT 4 and label all important anatomical features membranes etc Then illustrate and describe the transport or movement of Na Cl water and the amino acid glycine in or across this cell Indicate the mechanism behind the movement of these molecules at each border in as much detail as possible a b c d e g h i j k l m n 5 And a few final I D or No D from Dr Bill As saliva flows down the salivary ducts saliva HCO3 As blood P of O2 increases blood total CO2 As venous plasma pH increases venous P of O2 As protein in a meal increases urine pH As gastric pH decreases the duration of chyme digestion in the stomach f As intrapleural space pressure increases lung volume negative As lung volume increases lung compliance …