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Buffalo State PGY 452 - FINAL EXAM

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Abbreviations supplied with the testPHYSIOLOGY 452/552FINAL EXAMVERSION 1THURSDAY, MAY 12, 2016 INSTRUCTIONSThis examination consists of 45 questions, 12 pages (including this cover page). Please check that your copy has all pages.There is a table of abbreviations on page 12.Print your name and 8-digit UB person number on the answer sheet.Mark your answers on the answer sheet with a #2 pencil. If you erase, do so completely.WE DO NOT ANSWER QUESTIONS DURING THE EXAMINATION.You may keep the examination. Results and answer keys will be posted as soon as possible on UBLearns.WE NEED TO SEE YOUR UB ID CARD. If you have forgotten your card, please bring it to the Department Office (124 Sherman) within 24 hours.TO PREVENT CHEATING ON EXAMS Keep your answer sheet covered. Please inform one of the instructors if you suspect someone is cheating; (your comments will be kept confidential). Turn off all cell phones. BE SURE TO FILL IN TEST VERSION NUMBER ON THE SCANTRON On side two of your answer sheet (Scantron) there is a "Grade or Education" box below the "Identification box" where you add your student person number. In this box, fill in the appropriateversion number.BE ON TIME. No one will be allowed to start the exam after 8:20 am. 11. Which of the following is true of gap junctions in cardiac muscle? A. Pairs of hexamers assemble to form functional communication between cells B. Gap junctions are selective large pore channels C. Have a voltage sensor on the S4 alpha helix of each tetramer D. Facilitate electrical communication across the gap between the t-tubule and the sarcoplasmic reticulum E. None of the above 2. Whole body plethysmography is based upon Boyle’s Law and most often used to measure which of the following? A. Residual volume B. Expiratory reserve volume C. Inspiratory reserve capacity D. Total lung volume E. Tidal volume 3. It is estimated that in about 1/150,000 births, an individual is born with 46 chromosomes, bothan X and a Y chromosome, but is externally a phenotypic female at birth. A mutation in the gene for which protein is the most likely explanation for this condition? A. Androgen receptor B. Anti-Müllarian hormone C. Anti-Müllarian hormone receptor D. Estrogen receptor β E. Testes determining factor 4. A "morning after pill", or more accurately, emergency postcloital contraception, is a medication given to women in an attempt to prevent pregnancy after intercourse. In the US, the most widely prescribed medication for this purpose is levonorgestrel (Plan B). Because it is ineffective after implantation of the blastocyst into the endometrial wall, it must be administered within 72 hours of intercourse, and it is only effective if taken prior to ovulation. Levonorgestrel is an agonist for the receptor of which hormone? A. Progesterone B. 5-dihydrotestosterone C. Estriol D. Inhibin E. Chorionic gonadotropin 5. The primary signal detected by the peripheral chemoreceptors is 2A. an increase in PO2. B. a decrease in PO2. C. an increase in pH. D. a decrease in PCO2. E. none of the above. 6. What property or characteristic is shared by prolactin inhibiting hormone and estradiol? A. Enzymatic synthesis in a step-wise fashion B. Expression at high levels during lactation C. Binding to a nuclear receptor D. Low solubility in extracellular fluids E. A short half-life 7. The term for cutting the infundibulum between the pituitary and hypothalamus is hypophysectomy. One week after undergoing this procedure, which of the following hormone levels would be ABOVE normal? A. Anti-Müllarian hormone B. Chorionic gonadotropin C. Prolactin D. Inhibin E. Ghrelin 8. Kallmann's syndrome is a form of hypogonadism associated with a deficiency of GnRH-secreting neurons in the hypothalamus. What would be the effect on serum hormone concentrations in non-pregnant adult women with Kallmann's syndrome? A. Low gonadotropins and estrogens, normal androgens B. Normal gonadotropins, high estrogens, low androgens C. High gonadotropins, low estrogens and androgens D. Low gonadotropins, normal androgens and estrogens E. High gonadotropins and androgens, low estrogens 9. Which of the following is NOT involved in the disease cystic fibrosis? A. Synthesis of nonfunctional surfactant molecules B. Dysfunction of active transepithelial transport of chloride C. Dysfunction of ciliary motility D. Dysfunction of CFTR E. Inhibition of NaCl + water transport by airway epithelia 10. Which one of the following is NOT a function of the respiratory system? 3A. Speech and sound generation B. Exchanges oxygen and carbon dioxide between the air and the blood C. Protection against inhaled microorganisms D. Filters inhaled particulate matter E. Changes body pH by changing oxygen levels 11. The partial pressure of carbon dioxide in venous and arterial blood, respectively, in a healthyperson at rest is approximately A. 46 mmHg, 40 mmHg. B. 100 mmHg, 60 mmHg. C. 46 mmHg, 60 mmHg. D. 100 mmHg, 40 mmHg. E. 150 mmHg, 40 mmHg. 12. An EKG of Ventricular Tachycardia shows A. highly disordered sequence. B. a QRS complex followed by a T wave. C. a QRS complex preceded by a P wave. D. all of the above. E. none of the above. 13. Stimulation of the Vagus nerve will A. speed AV conduction velocity. B. slow heart rate. C. decrease the delay between atrial and ventricular excitation. D. all of the above. E. none of the above. 14. Which statement best describes the role of luteinizing hormone in supporting the development of spermatogonium? A. Up regulation of Sertoli cell aromatase synthesis B. Up regulation of adrenal androstenedione synthesis C. Up regulation of Leydig cell testosterone synthesis D. Down regulation of corpus albicans cytochrome P450SCC synthesis E. Up regulation of Leydig cell growth factor synthesis 15. Which is NOT true of Re-entrant Arrhythmias? A. Occurs when there is a “loop” of self excitation 4B. Occurs in Wolf-Parkinson-White syndrome C. Are faster than the normal rate of the Sino Atrial node D. Can arise from unidirectional or transient block E. All are true 16. Which of the following is characteristic of the signaling cascade initiated by prolactin binding to its receptor? A. Phosphorylation of a non-enzymatically active adapter protein B. Activation of a tyrosine kinase C. Activation of protein kinase A D. Hormone binding to a nuclear receptor E. Synthesis of intracellular inositol-3',4',5'-triphosphate 17. What property is shared by Sertoli cells and follicular-phase granulosa

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