U of M BIOC 3021 - Pre-class homework 24 KEY (2 pages)

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Pre-class homework 24 KEY



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Pre-class homework 24 KEY

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Pages:
2
School:
University of Minnesota- Twin Cities
Course:
Bioc 3021 - Biochemistry

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Name KEY BioC 3022 section 001 Author Number Day 24 Pre class homework 1 Give the function s encoded by each HIV gene a Gag core matrix and nucleocapsid proteins b Pol reverse transcriptase integrase protease c Env gp120 gp41 d Tat transactivator of transcription e Rev regulator of viral expression 2 What host molecules are required for fusion What viral molecules Host CD4 and CCR 5 Virus gp120 and gp41 3 What conformational changes take place in gp120 and gp4 see https www youtube com watch v RO8MP3wMvqg feature related Gp120 changes conformation upon attachment which allows gp41 to unfold hydrophobic tails that insert into the host cell membrane Once inserted gp41 refolds bringing the virus into contact with the host cell membrane 4 Why is the low fidelity of HIV reverse transcriptase an advantage for the virus By making frequent mistakes RT generates lots of variants Many are disadvantageous but a rare few can allow the virus to escape immune or drug pressure These variants can quickly expand to repopulate the patient 5 Why is the rev protein essential for HIV replication Rev allows export of unspliced mRNAs from the nucleus these unspliced mRNAs are essential because they serve as the genome for the next round of viruses 6 Why does the virus always win Rapid replication Strong selection for resistance Gradual loss of immune competence Latent T cells allow the virus to hide for decades 7 Why might a vaccine against HIV be difficult to develop The virus mutates rapidly so antibodies against the original virus aren t effective The most immunogenic parts of the viral surface proteins are not accessible to the immune system Name KEY BioC 3022 section 001 Author Number



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