UMass Amherst MICROBIO 160 - L20 Risk Factors for Skin Cancer (28 pages)

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L20 Risk Factors for Skin Cancer



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L20 Risk Factors for Skin Cancer

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Pages:
28
School:
University of Massachusetts Amherst
Course:
Microbio 160 - Biology of Cancer and AIDS

Unformatted text preview:

Risk Factors for Skin Cancer Skin Cancer qEach Year over 1 0 million people in the United States find out that they have skin cancer qEstimated new cases and deaths from melanoma in the United States in 2010 New cases 68 130 Deaths 8 700 qNon Melanoma New cases more than 1 000 000 Deaths less than 1 000 What are risk factors for skin cancer qHeredity people with a family history of skin cancer are generally at a higher risk of developing the disease People with fair skin and a northern European heritage appear to be most susceptible qEnvironment level of UV light today is higher than it was 50 or 100 years ago Ozone serves as a filter to screen out and reduce the amount of UV light that we are exposed to With less atmospheric ozone a higher level of UV light reaches the earth s surface qMultiple nevi moles or atypical nevi qOccupational exposure to coal tar pitch creosote arsenic compounds or radium qElevation UV is stronger as elevation increases because the thinner atmosphere at higher altitudes cannot filter UV as effectively as it does at sea level qLatitude the rays of the sun are strongest near the equator qCloud cover places with regular cloud cover may actually reduce UV resulting in a 50 percent lower level of UV light Skin Cancer Risk Factors Tanning beds as bad as tobacco Skin Cancer and Exposure to Sunlight The Electromagnetic Spectrum UVA with wavelength 315 400 nm UVB with wavelength 280 315 nm UVC with wavelength 100 280 nm What to look out for Effects of UV Radiation qUVB is the main cause of skin cancer also 1000 times more effective in causing sunburn qDamages DNA qOxidize lipids and produces harmful free radicals qCauses inflammation which also produces free radicals particularly nitrogen radicals qDisrupts cell communication and causes expression of stress response genes qWeakens the immune responses of the skin Origin of The Three Types of Skin Cancer Incidence and Mortality Rates for Different Types of Skin Cancer From L J Kleinsmith Principles



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