UMass Amherst BIOLOGY 285 - Bio SI Before Exam 3 (6 pages)

Previewing pages 1, 2 of 6 page document View the full content.
View Full Document

Bio SI Before Exam 3



Previewing pages 1, 2 of actual document.

View the full content.
View Full Document
View Full Document

Bio SI Before Exam 3

15 views


Pages:
6
School:
University of Massachusetts Amherst
Course:
Biology 285 - Cellular & Molecular Biology

Unformatted text preview:

Bio SI Before Exam 3 Herceptin Another example of a targeted cancer therapy Used to treat HER2 which is involved in breast cancer body overexpressing HER2 in breast cancer cells o Negative effect is not targeted to specific receptor will bind to whatever receptor it can bind to o Get a mutation in promoter gene that gets receptor to be overly expressed Monoclonal antibody not a small molecule antibodies are huge o Gleevec is a small molecule inhibitor Targets all HER2 receptors Antibodies Proteins that got produced by white blood cells Function is to bind to antigens which are foreign bodies non self ex viruses o Antibodies mark them for later destruction Variable domain where we get different variants of the antibodies Constant domain always the same Made up of heavy chain light chain one variable of each one constant of each 4 subunits Disulfide bond makes antibodies very stable Antigen bonds to variable because antigens can be anything can be different types so need antibody to be susceptible to bind to these How does variable region become variant o VDJ recombination Antibodies VDJ Recombination Variable region made up of V segments D segments and J segments o Regions in the DNA Recombination of the DNA makes up the variable region Can make up to 4 000 arrangements How can cell make sure it adds more variability to variant region o TDT polymerase that adds random nucleotides in between the segments o More than 4 000 antigens so need to add different nucleotides between segments to increase number of variability so can bind to all those antigens How does this cutting happen o RAG1 RAG2 cut DNA to make different segments and put them together o Same way CML cut Overview of Cell Cycle G1 phase growth gap phase o Could duplicate organelles o Cell checks environment Growth factor signals present Enough nutrients Enough energy DNA check for damage o Restriction point START G1 checkpoint prepare ingredients Make nucleotides Make proteins required for replication o Once



View Full Document

Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view Bio SI Before Exam 3 and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Bio SI Before Exam 3 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?