UMass Amherst BIOLOGY 285 - Bio 285 SI Before Quiz 4 (4 pages)

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Bio 285 SI Before Quiz 4



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Bio 285 SI Before Quiz 4

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4
School:
University of Massachusetts Amherst
Course:
Biology 285 - Cellular & Molecular Biology
Cellular & Molecular Biology Documents

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Bio 285 SI Notes Quiz 4 Cell cycle control system CDK enzyme called Cyclin dependent kinase o Cyclin is a binding partner o master cell cycle regulator o Any point in cell cycle that cells decide they need to stop inhibit CDK CDK is regulated in several ways o Cyclin regulation different cyclins for different phases of the cell cycle G1 cyclins telling CDK to target G1 proteins S phase cyclins M phase cyclins o Phosphorylation dephosphorylation by kinases and phosphatases 1 o CDK inhibitors CDKIs 2 Another way of regulation is the regulation of Cyclin levels 3 o Regulate the levels of the cyclin that binds CDK Cyclin levels rise and fall throughout cell cycle via o Transcription translation o Degradation through ubiquitin mediated proteolysis Difference between CDK and cyclin CDK is the car while cyclin is the key Cell cycle checkpoints G1 phase o Check for DNA damage before replication begins o Check for favorable environment o Must have enough material to create a duplication of the cell S phase o Check for errors incompletely duplicated DNA G2 phase o Damaged or incorrectly replicated DNA o Enough resources to continue M phase o Proper chromosome and microtubule attachment and arrangement If DNA gets messed up can stop it during those checkpoints S G2 do basically the same thing Summarize whole cell cycle by putting each step in each stage Overview of cell cycle G1 phase growth gap phase o Could duplicate organelles o Cell checks environment Growth factor signals present Enough nutrients Enough energy DNA check for damage o Restriction point START G1 checkpoint o Prepare for DNA replication prepare ingredients Make nucleotides Make proteins required for replication o Once replication starts cell now in S phase S phase synthesis phase o DNA replication G2 phase 2nd growth phase o Check for DNA damage o Finish replication o Prepare for M phase M phase chromosome segregation o Cytokinesis splitting of the cytosol G0 phase non dividing state o Stop replication o Cell



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