UMass Amherst BIOLOGY 285 - Bio 285 SI Before Quiz 3 (2 pages)

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Bio 285 SI Before Quiz 3



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Bio 285 SI Before Quiz 3

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2
School:
University of Massachusetts Amherst
Course:
Biology 285 - Cellular & Molecular Biology
Cellular & Molecular Biology Documents

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Bio 285 SI Notes before Quiz 3 Pre IC pre initiation complex o Set of proteins necessary for DNA polymerase to successfully bind to DNA to start its activity Quiz covers Brc Abl light coverage since already tested on it G1 restriction point S phase a little anything on cell cycle o Antibodies not on it fake news Abl is generally involved in cell signaling pathways has kinase activity that allows it to interact with cell division pathways and growth pathways lot of different signal transduction pathways o Basically works with those pathways and plays a role in allowing them to occur o Mutated into Bcr Abl bring two kinase domains into close contact which means that they are able to cross phosphorylate and therefore more easily able to get activated due to mutation This is what gives you overactivity in kinase part of Bcr Abl o Also have Bcr but not functioning normally o Bcr takes part in DNA damage pathways normally activates pathways that prevent cell cycle from occurring o Mutated Bcr Abl tumor suppressive activities don t occur properly Origin of replication is the point on the chromosome where pre replication complex is going to form Pre replication complex is a set of 4 different proteins that are all necessary for the pre initiation complex to form o Recruits downstream proteins later on into pre initiation complex and then from there are able to replicate DNA During G1 phase what is main aspects is you have to make the proteins that are going to drive replication so have to prep for S phase to occur before pass restriction point to go into S phase some of the proteins made are Mcms CDT1 CDC6 etc Bubble break area that starts to form protein complex origin of replication ORI have protein called ORC o Once ORC is present on DNA recruits two other proteins CDT1 and CDC6 o Makes up three main components that need to come together before fourth complex comes in helicase o Has to be bound in such a way that it is enclosed around DNA b c will separate DNA strands



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