UMass Amherst BIOLOGY 285 - Bio 285 Review Exam 2 (3 pages)

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Bio 285 Review Exam 2



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Bio 285 Review Exam 2

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Pages:
3
School:
University of Massachusetts Amherst
Course:
Biology 285 - Cellular & Molecular Biology

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Bio 285 Exam 2 Review Laura Allostery a molecule that binds an enzyme somewhere other than the active site and controls the enzyme s function o To regulate activity o Causes enzyme to change shape activity Mechanism of enzyme function stuff mechanism of protein regulation stuff should know for exam basically memorize slides Memorize pathways for exam Q What makes it an active site o Enzyme is a molecule usually a protein that catalyzes a chemical reaction active site defined as where substrate binds where chemical reaction occurs o Binding to somewhere other than the active site changes enzyme shape affects ability to bind substrates change ability to catalyze chemical reaction have to be in active site to catalyze chemical reaction Q intrinsic kinase activity vs extrinsic kinase activity o Intrinsic kinase activity of thing you re talking about its own kinase activity o Extrinsic kinase activity of another molecule Autophosphorylation increases intrinsic kinase activity Wildtype Abl kinase may dimerize autophosphorylate don t run around the cell as dimers o Bcr gives them capability to tetramerize or polymerize brings two relations in close to each other and that cross phosphorylation activates that kinase activity Know parts of Abl skip Bcr Abl stuff how does Abl control itself autoinhibitory function how regulated Ras GEF GAP stuff should know Ras mutations cause cancer Ran mutations do not o Ras and Ran structurally related but who Ran and Ras bind to are different o Ran GEF GAP different from Ras GEF GAP o Essentially molecular switches o Ras GDP bound state molecular switch things to be regulated in cell Q compare contrast Ras G proteins o Less related Bad s function is to inhibit Bcl2 o For survival of cells want Bad to be off o But sometimes cell survival is not right thing sometimes cell should be activating programmed cell death pathways Not having programmed cell death not regulating it correctly can be not good o Bad s function is to bind Bcl2 then



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