EKU NSC 330 - pharm week 2 (14 pages)

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pharm week 2



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pharm week 2

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Pages:
14
School:
Eastern Kentucky University
Course:
Nsc 330 - Clinical Drug Therapy

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Drugs Affecting Adrenergic Function Autonomic Nervous System Involuntary system responsible for control of smooth muscles Bronchi Blood vessels GI tract Cardiac muscles Exocrine gastric sweat and salivary SNS and PSNS Effects on the Body Medication function Pharmacological drugs work on the receptors by either Increase Agonist Decrease Antagonists anti Neurotransmitters of ANS Acetylcholine Dopamine Norepinephrine Epinephrine Adrenergic Agonists Fight or Flight System These drugs mimic the action of the sympathetic nervous system 2 groups Catecholamine o Short duration action o Cannot be given orally o They do not cross the blood brain barrier Non catecholamine Classified according to their selectivity Nonselective acting Selective acting Adrenergic Receptors Alpha 1 Alpha 2 Beta 1 Beta 2 Adrenergic Receptors Alpha 1 Arteries Veins Bladder Eyes Male Sex Organs Alpha 2 Inhibits Norepinephrine Release Adrenergic Receptors Beta 1 Heart Kidney Beta 2 Bronchi Skeletal Muscle Arterioles Uterus Dopamine Kidneys Non Selective Prototype Epinephrine Pharmacotherapeutics Wide variety of indications asthma shock anaphylactic reaction ventricular fibrillation Pharmacokinetics Adminstered parenterally topically or by inhalation Metabolized in the liver and excreted through the kidneys Pharmacodynamics It stimulates all adrenergic receptors except dopaminergic and causes the greatest adverse effects in the cardiovascular system and CNS Epinephrine Contraindications and precautions Absolute contraindications to epinephrine include hypersensitivity sulfite sensitivity closed angle glaucoma and its use during labor Adverse effects hypertensive crisis angina cerebral hemorrhage cardiac arrhythmias elevated serum glucose J Drug interactions Beta blockers Selective adrenergic agonists Nonselective acting Activate both alpha and beta receptors Selective acting Alpha 1 Arteries veins bladder eyes Male sex organ Alpha 2 Inhibits norepinephrine release Beta 1 Heart Kidney Beta 2 Arterioles



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