TAMU BIOL 213 - Practice_Final_F17 (5 pages)

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Practice_Final_F17



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Practice_Final_F17

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Texas A&M University
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Biol 213 - Molecular Cell Biol
Molecular Cell Biol Documents
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BIOL 213 504 Final Exam Study Guide PART 1 Multiple Choice Circle the best answer s 1 Lipid derived secondary messengers are generated by the action of a phosphatases b phosphodiesterases c phospholipases d phosphoribosyl transferases e none of the above 3 The codons for amino acids are a triplet b overlapping c degenerate d a and c 4 The nucleosomal core histones include a H1 H2A H2B and H3 b H1 H2A H2B and H4 c H2A H2B H3 and H4 d H1 H3 H4 and H5 e none of the above 5 The DNA binding domains of DNA binding proteins most likely do not include a acidic amino acids b hydrophobic amino acids c basic amino acids d a and b 6 Which of the following is not a property of stem cells a They are self renewing b Under appropriate conditions they can differentiate into different cell types and tissues c They have great medical potential d They always come from embryos e None of the above 7 Caspases are a DNA repair enzymes b kinases c phosphatases d phosphodiesterases e proteases 8 Many human tumors carry mutations in a caspases b p21 c p53 d PolI e b and c 9 Proteins that bind enhancer sequences almost always a have basic amino acids in their DNA binding domains b bind cis regulatory elements upstream of the core promoter they regulate c bind to pre mRNAs d a and b 10 The implications of alternative splicing are a the same transcription unit can encode several different proteins b gene expression can be regulated at the post transcription level c evolution of new gene functions is facilitated d a and b e a b and c 11 ras is a an oncogene b a tumor suppressor gene c a transcription factor d none of the above e a b and c 12 p53 is a an indirect inhibitor of cyclin dependent kinase b a tumor suppressor gene c a transcriptional activator of p21 d none of the above e a b and c 13 How many transmembrane helices does a G protein coupled receptor have a 6 b 7 c 10 d 12 e 14 14 The exonuclease activities of DNA polymerase I are used to a replicate the E coli chromosome b proofread newly synthesized strands c maximize the fidelity of replication d b and c e a b and c 15 Semiconservative replication means that a each daughter strand will have one of the parental strands and one new strand b one daughter duplex will be entirely new and the other will have both original parental strands c both daughter duplexes will be entirely new and the parental duplex will be degraded d each strand of each daughter duplex will have parts of the parental strands and parts of new strands 16 p21 a is an inhibitor of G1CDK b acts during cell differentiation to block the cell cycle at G1 S c is transcribed from a promoter activated by p53 d none of the above 2 e a b and c 17 Two of the main checkpoints in the cell cycle occur at the transitions between a G0 G1 and G1 S b G1 S and S G2 d S G2 and G2 M e M G1 and S G2 f G1 S and G2 M 18 Which is not true of the double helix a G C b A T c 20 diameter d Two nucleotide chains are oriented in the same direction ie parallel e all are true 19 The term helix refers to a feature of a Protein primary structure b Protein secondary structure c Protein tertiary structure d Protein quaternary structure e Random coiling 20 Acetylcholine is released at a The chloroplast membrane b The myelin sheath c Synaptic junctions d The nucleus e The red blood cell membrane 21 How many net ATPs are produced for each glucose molecule that enters glycolysis a 2 b 3 c 4 d 5 e 6 22 Which of the following proteins are not components of the cytoskeleton a Tubulin b Actin c Collagen d a and c e All are components of the cytoskeleton 23 Which of the following is the most common second messenger a Cyclic AMP cAMP b ATP c GTP d phosphoribosyl transferases e None of the above 3 24 Which of the following statements about histones is not true a Histones have similar sequences among all eukaryotic species b Histones have many basic amino acids c Histones are rich in lysine and arginine d Histones H1 H2B H3 and H4 form the nucleosomal core e All four of these statements are true PART 2 The part where you have to write something 25 Provide the appropriate word or phrase a When chromatin is treated with DNase I the resulting DNA fragments have a length of about base pairs b In mRNA the codons for amino acids are and c DNA polymerase is the enzyme primarily responsible for the replication of the E coli chromosome e The anti leukemia drug acts by inhibiting the hyperactive protein kinase encoded by the Abl oncogene g The DNA binding domains of DNA binding proteins most likely include amino acids i According to the endosymbiont theory eukaryotic cells evolved by the acquisition of photosynthetic and or aerobic non photosynthetic bacteria that ultimately evolved into the current organelles and j is the process of programmed cell death 26 Match the most appropriate words or phrases Write the appropriate letter in column 2 in the appropriate space in column 1 1 2 Messelson and Stahl a Tumor suppressor gene Okazaki fragments b Watson Crick Gunter Blobel c A T G C Double Helix d DNA Polymerase I Peyton Rous e NADP NADPH Chargaff f Pioneers in mammalian transcription factors Arthur Kornberg g Semi conservative DNA replication McKnight Tijan h DNA replication initiation Photosynthesis i Signal hypothesis P53 j Receptor tyrosine kinase RTK k Avian sarcoma virus 4 28 THIS IS A CENTRAL DOGMA QUESTION Schematically outline the flow of genetic information from the nucleus to the cytoplasm and describe potential regulatory mechanisms at each step 29 THIS IS A CENTRAL DOGMA QUESTION A Draw a typical RNA polymerase transcription unit Label the key features and explain the potential regulatory roles Hint Include at least three exons B Schematically outline the splicing of one of the introns Be specific 30 Name a drug that has been developed that targets transcription What is its target and what human disease is it directed at 31 What distinguishes a eukaryotic cell from a prokaryotic cell 5


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