UMD BCHM 461 - testbank-4e-CH05 (9 pages)

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testbank-4e-CH05



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testbank-4e-CH05

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Pages:
9
School:
University of Maryland, College Park
Course:
Bchm 461 - Biochemistry I
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Chapter 5 Protein Function Multiple Choice Questions 1 Reversible binding of a protein to a ligand oxygen binding proteins Page 157 Difficulty 2 Ans D The interactions of ligands with proteins A B C D E are relatively nonspecific are relatively rare in biological systems are usually irreversible are usually transient usually result in the inactivation of the proteins 2 Reversible binding of a protein to a ligand oxygen binding proteins Page 158 Difficulty 1 Ans D A prosthetic group of a protein is a non protein structure that is A B C D E a ligand of the protein a part of the secondary structure of the protein a substrate of the protein permanently associated with the protein transiently bound to the protein 3 Reversible binding of a protein to a ligand oxygen binding proteins Pages 158 159 Difficulty 2 Ans B When oxygen binds to a heme containing protein the two open coordination bonds of Fe2 are occupied by A B C D E one O atom and one amino acid atom one O2 molecule and one amino acid atom one O2 molecule and one heme atom two O atoms two O2 molecules 4 Reversible binding of a protein to a ligand oxygen binding proteins Pages 160 161 Difficulty 2 Ans A In the binding of oxygen to myoglobin the relationship between the concentration of oxygen and the fraction of binding sites occupied can best be described as A B C D E hyperbolic linear with a negative slope linear with a positive slope random sigmoidal 52 Chapter 5 Protein Function 5 Reversible binding of a protein to a ligand oxygen binding proteins Page 160 Difficulty 2 Ans E Which of the following statements about protein ligand binding is correct A B C D E The Ka is equal to the concentration of ligand when all of the binding sites are occupied The Ka is independent of such conditions as salt concentration and pH The larger the Ka association constant the weaker the affinity The larger the Ka the faster is the binding The larger the Ka the smaller the Kd dissociation constant 6 Reversible binding of a protein to a ligand oxygen binding proteins Page 163 Difficulty 2 Ans E Myoglobin and the subunits of hemoglobin have A B C D E no obvious structural relationship very different primary and tertiary structures very similar primary and tertiary structures very similar primary structures but different tertiary structures very similar tertiary structures but different primary structures 7 Reversible binding of a protein to a ligand oxygen binding proteins Page 165 Difficulty 2 Ans B An allosteric interaction between a ligand and a protein is one in which A B C D E binding of a molecule to a binding site affects binding of additional molecules to the same site binding of a molecule to a binding site affects binding properties of another site on the protein binding of the ligand to the protein is covalent multiple molecules of the same ligand can bind to the same binding site two different ligands can bind to the same binding site 8 Reversible binding of a protein to a ligand oxygen binding proteins Page 165 Difficulty 1 Ans C In hemoglobin the transition from T state to R state low to high affinity is triggered by A B C D E Fe2 binding heme binding oxygen binding subunit association subunit dissociation 9 Reversible binding of a protein to a ligand oxygen binding proteins Pages 171 172 Difficulty 2 Ans C Which of the following is not correct concerning 2 3 bisphosphoglycerate BPG A B C D E It binds at a distance from the heme groups of hemoglobin It binds with lower affinity to fetal hemoglobin than to adult hemoglobin It increases the affinity of hemoglobin for oxygen It is an allosteric modulator It is normally found associated with the hemoglobin extracted from red blood cells Chapter 5 Protein Function 53 10 Reversible binding of a protein to a ligand oxygen binding proteins Page 167 Difficulty 2 Ans C Which of the following is not correct concerning cooperative binding of a ligand to a protein A B C D E It is usually a form of allosteric interaction It is usually associated with proteins with multiple subunits It rarely occurs in enzymes It results in a nonlinear Hill Plot It results in a sigmoidal binding curve 11 Reversible binding of a protein to a ligand oxygen binding proteins Page 173 Difficulty 1 Ans D The amino acid substitution of Val for Glu in Hemoglobin S results in aggregation of the protein because of interactions between molecules A B C D E covalent disulfide hydrogen bonding hydrophobic ionic 12 Reversible binding of a protein to a ligand oxygen binding proteins Page 173 Difficulty 2 Ans C The fundamental cause of sickle cell disease is a change in the structure of A B C D E blood capillaries hemoglobin red cells the heart 13 Complementary interactions between proteins and ligands the immune system and immunoglobulins Page 175 Difficulty 2 Ans B An individual molecular structure within an antigen to which an individual antibody binds is as a n A B C D E antigen epitope Fab region Fc region MHC site 14 Complementary interactions between proteins and ligands the immune system and immunoglobulins Page 176 Difficulty 2 Ans A The proteins of the Major Histocompatibility Complex MHC bind and display A B C D E antigen fragments B cell fragments immunoglobin fragments macrophage fragments T cell fragments 54 Chapter 5 Protein Function 15 Complementary interactions between proteins and ligands the immune system and immunoglobulins Page 178 Difficulty 3 Ans B Which of the following parts of the IgG molecule are not involved in binding to an antigen A B C D E Fab Fc Heavy chain Light chain Variable domain 16 Complementary interactions between proteins and ligands the immune system and immunoglobulins Page 180 Difficulty 3 Ans C A monoclonal antibody differs from a polyclonal antibody in that monoclonal antibodies A B C D E are labeled with chemicals that can be visualized are produced by cells from the same organism that produced the antigen are synthesized by a population of identical or cloned cells are synthesized only in living organisms have only a single polypeptide chain that can recognize an antigen 17 Protein interactions modulated by chemical energy actin myosin and molecular motors Page 182 Difficulty 2 Ans A Which of the following generalizations concerning motor proteins is correct A B C D E They convert chemical energy into kinetic energy They convert chemical energy into potential energy They convert kinetic energy into chemical energy They convert kinetic energy into rotational energy They convert


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