UCSB EEMB 2 - Computational Set #5 (8 pages)

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Computational Set #5



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The ultimate source of genetic variation The ultimate source of genetic variation Mutation rates in humans are approximately 10 9 changes per base pair per generation Each human gamete contains 3 x 109 base pairs Mutation rates in humans are approximately 10 9 changes per base pair per generation Each human gamete contains 3 x 109 base pairs On average how many new mutations would a human diploid zygote carry On average how many new mutations would a human diploid zygote carry a 3 b 30 c 6 d 60 a 3 b 30 c 6 d 60 1 Fitness W The ultimate source of genetic variation Mutation rates in humans are approximately 10 9 changes per base pair per generation Each human gamete contains 3 x 109 base pairs On average how many new mutations would a human diploid zygote carry a 3 b 30 c 6 3 109 10 9 2 d 60 This translates to about 42 billion new mutations in the current human population Describes rates of survival and reproduction of individuals by a class of organisms Relative fitness Average number of surviving offspring of a genotype compared to other competing genotypes One genotype is normalized at W 1 and the other genotypes are compared to that genotype taking any non negative value including 0 Relative fitness W individual genotype reproduction rate highest reproduction rate 2 3 4 5 6 7 8


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