CSU MIP 315A - lecture2 Bacteria-2-2 (79 pages)

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lecture2 Bacteria-2-2



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lecture2 Bacteria-2-2

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Pages:
79
School:
Colorado State University- Fort Collins
Course:
Mip 315a - Human and Animal Disease
Human and Animal Disease Documents

Unformatted text preview:

A Brief History Archaebacteria and Eubacteria from 3 8 billion years ago First Mammals 0 2 billion years ago First hominins 004 billion years ago Over 3 7 billion years later Australopithecus Deep Sea Vents What Bacteria Did with Their Head Start Over 1029 Total Organisms Greatest Mass Greatest Diversity Greatest Distribution Is now and always has been the age of bacteria Biologically the most successful living things on Earth One Carrier Roughly 100 000 tons 1013 Human 1013 Bacteria Objectives Lecture 2 Describe the nature and function of the normal flora Know the general characteristics of bacteria Explain how intracellular bacteria cause disease Describe how endotoxins cause shock Describe how exotoxins cause disease Explain the pathogenesis of salmonella Explain how antibacterial antibiotics work Normal Flora DNA surveys of the belly button inner elbows and elsewhere reveal diverse microbial communities Belly button has many more bacteria than between the toes 10 000 000 bacteria per square centimeter in skin punches compared to 10 000 in skin scrapes Representation of the microbial and molecular diversity using the Shannon index comparing samples based on their microbial 16S rRNA amplicon or molecular UPLC QTOF MS profiles Amina Bouslimani et al PNAS 2015 112 E2120 E2129 2015 by National Academy of Sciences Distribution Gut Flora Gut Flora and Behavior I Commensal bacteria play a role in mating preference of Drosophila melanogaster Gut Flora and Behavior II One experiment involved replacing the gut bacteria of anxious mice with bacteria from fearless mice The mice became less anxious more gregarious says Stephen Collins of McMaster University in Hamilton Ontario who led a team that conducted the research Lousy Sex Wood Louse The vast majority of of animals are insects 20 percent of all insects are infected with Wolbachia Isopod http www extension iastat e edu CropNews 2010 052 5hodgson htm All have given up sexual reproduction Bacteria and Individuality Identical twins may share appearances mannerisms even clothes but the microbes living in their guts are anything but the same Communities of bacteria in adult identical twins differ dramatically Bacterial Commerce Classification a Spherical Cocci Rod like Bacilli or Spiral Spirochetes in Shape b Gram negative gram positive Basic Bacterium Bacterial Pathogenesis Attachment to and Invasion of cells followed by cellular destruction or alteration of cellular physiology Bacteria Grow in Body Fluids e g Blood Septicemia or Bacteremia and Urine Bacteuria Production of Toxins Biofilms Gram Staining Gram Vs Gram Gram Negative Gram Positive http www rsc org chemistryworld 2013 09 antibiotics drugresistant bacteria Action of Endotoxins Inflammation Septic Shock Septic or Endotoxic Shock Exotoxins Soluble factors usually proteins secreted by living bacteria Bind to specific receptors on host cells and interfere with normal cell function E Coli 0157 H7 November 2009 Beef Recall recalled almost 546 000



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