DOC PREVIEW
CSU MIP 315A - Lecture 27 Skin (1)

This preview shows page 1-2-3-4-31-32-33-34-35-63-64-65-66 out of 66 pages.

Save
View full document
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience
Premium Document
Do you want full access? Go Premium and unlock all 66 pages.
Access to all documents
Download any document
Ad free experience

Unformatted text preview:

Objectives Lecture 27Naked babyElephant skinRhino skinOld skinSkin micrographMitesSkinSkinCells and layersSlide 11KeratinocytesSkinMelanocytesIIMelanin and basal cellsLangerhans cell SEMLangerhan’s cellsLesionsManifestations of skin disordersrashPruritusSunburnUltraviolet LightSlide 25UVAUVBSlide 28Basal Cell CarcinomasBasal Cell CarcinomasSquamous cell CarcinomasSquamous Cell CarcinomasMelanomaMelanoma Is a Different StoryAdequate Sunburn protectionInfectious DiseasesMicrosporum canisTinea corporisSlide 39staphylococciImpetigoNecrotizing fasciitisIIEtiology and PathogenesisRisk FactorsHerpes simplex type IIGenital Herpes SymptomsFemaleMaleSlide 50Slide 51AcneHair folliclepimpleIIIIIAcne vulgarisSlide 58EczemaIISpreading eczemaEtiologySlide 63UrticariaType I hypersensitiviyObjectives Lecture 31Objectives Lecture 27•Describe the basic elements of the skin•Explain the role of sunlight in skin cancer•Describe the basic mechanisms of infectious diseases of the skin•Describe the etiology and pathogenesis of acne•Explain the role of the immune system in eczema and urticariaNaked babyElephant skinRhino skinOld skinSkin micrographMitesSkinSkinCells and layersKeratinocytesSkinMelanocytesIIMelanin and basal cellsLangerhans cell SEMLangerhan’s cellsLesions•A lesion is a non-specific term referring to abnormal tissue in the body. It can be caused by any disease process including trauma (physical, chemical, electrical), infection, neoplasm, metabolic and autoimmuneManifestations of skin disordersrashPruritus•Pruritus is a common manifestation of dermatologic diseases, including xerotic eczema, atopic dermatitis, and allergic contact dermatitis.SunburnUltraviolet LightUV-C (100-280 nm) radiation is filtered out by ozone in the stratosphere. Only a small amount reaches the earth’s surface.UV-B (280-320 nm) radiation poses a threat to life on earth even though some of it is filtered out by ozone in the stratosphere. The cumulative exposure of UV-B radiation may cause sunburn, cataracts, suppressed immune systems, premature aging including; wrinkles and skin discolorations as well as skin cancer. UV-A (321-400 nm) requires 103 times more than UV-B to produce sunburnUVAUVA also increases the damaging effects of UVB, including skin cancer and cataracts (an eye disorder characterized by a change in the structure of the crystalline lens that causes blurred vision).UVBUVB rays1can directly damage skin cells’ DNA, and are the main rays that cause sunburns. They are also thought to cause most skin cancers.Basal Cell CarcinomasBasal Cell Carcinomasare slow-growing cancers that rarely metastasizes and is almost never fatal. About 75 percent of skin cancers are basal cell carcinomas, which usually develop on sun-exposed areas like the head and neck.Squamous cell CarcinomasSquamous Cell Carcinomasare less common. In rare cases, it can spread and be life threatening. Accounting for one-fifth of all skin cancers, squamous cell carcinoma is directly related to sun exposure. It occurs on the most sun-exposed areas, such as the head and neck.MelanomaMelanoma Is a Different StoryMelanoma occurs in the pigment-producing cells of the epidermis. Melanoma can be deadly, but it is often curable if caught early. It can occur anywhere, not just in sun-exposed skin. About 70 percent of melanoma cases develop in normal skin, while only 30 percent develop in moles. It can occur anytime, and is not strongly associated with lifetime accumulation of sun exposure. Some experts believe melanoma is linked to a few severe sunburns in childhoodAdequate Sunburn protectionInfectious DiseasesFungalSuperficial mycosesBacterialStaphylococci and StreptococciViralHerpesMicrosporum canisTinea corporisstaphylococciImpetigoNecrotizing fasciitisIIEtiology and PathogenesisGroup A beta hemolytic streptococci and others including staph and clostridiaPathology due to production of bacterial exotoxinsApproximately 25% mortalityRisk FactorsHave a weak1immune system.Have chronic health problems such as diabetes,1cancer, or1liver1or1kidney1disease.Have cuts in your1skin, including surgical wounds.Recently had1chickenpox1or other1viral infections1that cause a1rash.Use steroid medicines, which can lower the body's resistance to infection.Herpes simplex type IIGenital Herpes Symptoms Swollen glands in the groin Discharge from the vagina or penis Painful or difficult urination Fever Headache Muscle acheFemaleMaleAcneHair folliclepimpleIIIIIAcne vulgaris Acne culprit 1: Hormones. In acne sufferers the sebaceous glands are overstimulated by androgens Acne culprit 2: Extra sebum. When the sebaceous gland is stimulated by androgens, it produces extra sebum. The sebum mixes with common skin bacteria and dead skin cells that have been shed from the lining of the follicle. While this process is normal, the presence of extra sebum in the follicle increases the chances of clogging — and acne. Acne culprit 3: Bacteria. The bacterium Propionibacterium acnes. Once a follicle is plugged, P. acnes bacteria multiply rapidly, causing inflammation in the follicle and surrounding skin.EczemaIISpreading eczemaEtiologyThe exact cause of eczema is not known. It is activated by the immune system and is related to allergic reactions. Contact with the external trigger (allergen) causes the skin to become inflamed. The duration of the contact is not important. Eczema can develop on first contact (in days to weeks) or over time with repeated contact (in months to years).Risk factors for eczema include the following: People with severe eczema usually also have hay fever and asthma. Eczema is probably hereditary and often is found in other family members. Eczema is not contagious.Risk factors for an eczema flare include the following: Illness Physical or mental stress Exposure to skin irritantsUrticariaType I hypersensitiviyObjectives Lecture 31Know the basic elements of the skinUnderstand sunburnUnderstand the basic mechanisms of infectious diseases of the skinKnow the etiology and pathogenesis of acneKnow the pathogenesis of eczemaUnderstand the immunology of


View Full Document

CSU MIP 315A - Lecture 27 Skin (1)

Documents in this Course
Load more
Download Lecture 27 Skin (1)
Our administrator received your request to download this document. We will send you the file to your email shortly.
Loading Unlocking...
Login

Join to view Lecture 27 Skin (1) and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Lecture 27 Skin (1) 2 2 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?