2016 Spring Neurobiology ZOO 3744 A001 This lecture will be tested Slide 1 Neuroscience Exploring the Brain 3rd Ed Bear Connors and Paradiso Copyright 2007 Lippincott Williams Wilkins 2016 Neuroscience Exploring the Brain Bear Neuroscience Animals Behavior Contents 2015 edition new Neurobiology Advanced Neurobiology Ch 1 8 11 12 24 2016 Summer A Ch 9 10 13 16 18 22 24 25 2016 Summer B Slide 3 Ch 2 4 Ch 2 8 Ch 2 8 Slide 4 Multiple choices Any special needs Come to see me Slide 5 http www youtube com watch v zLpedwiGUU 11 minutes Neuron to neurons connections and communications Lightening action potentials neural messages Brain inventions To teach the next generation Development learning and memory Bear Neuroscience Exploring the Brain Chapter 01 Neuroscience Past Present and Future Chapter 1 will not be tested Slide 10 Brain Functions Lateralization and Localization Each lobe has special functions Check out slide Different areas of the brain do different things Sensory Pathways and cortexes Gustatory cortex Primary somatic sensory cortex Olfactory cortex Auditory cortex Olfactory bulb Visual cortex 1 Eye 2 2 Most sensory pathways project to the thalamus The thalamus modifies and relays information to cortical centers Nose 1 Cerebellum Thalamus Sound Brain stem Equilibrium 3 3 Tongue Spinal cord Somatic senses Brain Functions Seeing Emergent Property Gestalt psychology 1 1 2 Brain Functions Emergent Property Rubber hand Illusion This illusion happens as a result of the interaction of multiple sensory systems vision touch and position sense Stab the rubber hand may cause fear When brain goes crazy General epileptic seizures wild electrical activity Epilepsy from the Ancient Gree k epil ps a to seize is a common chronic neurological disorder characterized by seizures These seizures are transient signs and or symptoms of abnormal excessive or synchronous neuronal activity in the brain About 50 million people worldwide have epilepsy http www youtube com watch v CDccChHrgRA Partial http www youtube com watch v e10FSjHvV74 Generalized http www youtube com watch v w5Jv0SZRwwk Diagnosis http www youtube com watch v 6NcqQkKjqTI http www youtube com watch v 6NcqQkKjqTI feature related http www youtube com watch v 2HFfx V yPI feature endscreen NR 1 Slide 15 Alzheimer s disease Sulcus a groove or fissure http www youtube com watch v IcuDz7tO L7E feature relmfu Slide 16 Slide 17 Neuroscience Exploring the Brain 3rd Ed Bear Connors and Paradiso Copyright 2007 Lippincott Williams Wilkins Frontal damage behavioral changes Slide 18 Death by Lethal Injections decision making Brain death and heart death Living fossil Slide 19 2013 Neuroscience Meeting Slide 20 Introduction of the chapter Neuroscience Study of the nervous system brain spinal cord peripheral nerves local ganglia The conclusion is the subject of this course Neuroscience neurobiology physiological psychology Behavioral Neuroscience Molecular Neuroscience Brain Functions neurology etc Court room neuroscience Various aspects of human nature Sensations e g temperature pain movement curiosity pleasure reasoning learning memory emotion and madness decision etc An integrative science psychology biology medicine chemistry physics mathematic modeling computer simulation David Marr s book in 1982 Vision Currently neural network research is very active The Society for Neuroscience development in the last 40 years is fast from a couple of hundreds to over 40 000 neuroscientists Slide 21 32 000 Slide 22 Slide 23 Neuroscience Exploring the Brain 3rd Ed Bear Connors and Paradiso Copyright 2007 Lippincott Williams Wilkins https www sfn org annualmeeting neuroscience 2015 sessions andevents scientific program Neuroscience Exploring the Brain 3rd Ed Bear Connors and Paradiso Copyright 2007 Lippincott Williams Wilkins Slide 24 Women are leaders Slide 25 Slide 26 Neuroscience Exploring the Brain 3rd Ed Bear Connors and Paradiso Copyright 2007 Lippincott Williams Wilkins Dr Cheng and his Current Graduate student Jeff Hatcher Ph D to be Slide 28 Dr Cheng and his previous postdoctoral Fellow Dr Alex Gu MD Ph D Slide 29 Scott Harden Ph D Student Slide 30 Publishers Slide 31 Neuroscience Exploring the Brain 3rd Ed Bear Connors and Paradiso Copyright 2007 Lippincott Williams Wilkins Tons of books Slide 32 Neuroscience Exploring the Brain 3rd Ed Bear Connors and Paradiso Copyright 2007 Lippincott Williams Wilkins Our new text book Neuroscience Exploring the brain Slide 33 Fun and easy to learn hard concepts and Long Term Memory Retention 2016 Spring Electives Sorry Full now 2016 Summer B Mix mode Restrictive Electives Counted as a lab course Also offered in Summer B 2016 Slide 34 Laboratory Virtual Simulation in Physiology 2016 Spring or Summer Demo Exercise 7 The brain controls the cardiac output and vascular resistance through autonomic nerves Sympathetic nerve Red Green accelerate heartbeat Accelerator increases blood vessel resistance Parasympathetic vagal nerve Blue Yellow slows heartbeat Brake Dr Cheng s Research Dr Cheng s Lab In Vivo Physiological Nerve Recording System My postdoctoral fellow He GU got this national award An actual experiment in Dr Cheng s lab FVB control and OVE26 Type 1 transgenic diabetic mice age 5 6 months were used Anesthesia 1 isoflurane inhalation heart Aortic depressor nerve activity ADNA recording changes of baseline integrated ADNA in response to SNP PE induced MAP changes were fitted to sigmoidal logistic function curve under isoflurane anesthesia Y P1 1 exp P2 X P3 P4 tracer Labeled Nerve Catheterizations left femoral artery to monitor arterial pressure AP both left and right femoral veins to infuse drugs Sodium Nitroprusside Copyright 2009 Pearson Education Inc SNP Phenylephrine PE Vasoactive drugs vasoconstriction and vsaodilation Anterograde Labeling of Aortic Arch Baroreceptors and Afferent Fibers Carotid Body Nodose Ganglion Vagus Nerve Carotic Sinus Nerve Baroreceptors and Afferents Labeled Aortic Body TMR D Li L et al Structural remodeling of Vagal Afferent Innervation of Aortic Arch in Transgenic Mice of type I diabetes OVE 26 J Comp Neurol 2010 Original recordings of phasic arterial pressure PAP aortic depressor nerve activity ADNA integrated Int ADNA and Electrocardiogram ECG PAP mmHg 90 80 70 ADNA uV Action potentials 50 0 Int ADNA uV s 50 0 2 0 1 0 0 ECG mV 0 4 0 2 0 0 0 2 0 5 1 0 1 5 Time second Copyright 2009 Pearson Education Inc 2 0 Compound action potentials NeuroPhysiology Cardiovascular Physiology