MCB 252 Topic 20 Stable Actin StructuresProf David Rivier MCB 252 Spring 2015 Topic 20 Stable Actin Structures Reading Lodish 17 4 Outline Actin Cytoskeleton A Properties of Actin B Role of Actin in Cell Movement C Regulation of Actin Assembly in Cells D Stable Actin Structures E Muscle Cells and Myosin Motors Actin Binding Proteins Cross linking proteins interact with actin filaments to form bundles or networks Adaptor proteins link actin filaments to membranes Microvilli Microvilli From MCB 150 Different Types of Bundles for Different Jobs Filaments capped and relatively stable Red Blood Cells Must be deformable to squeeze through small capillaries RBC Cytoskeleton Lodish 17 21a An ordered array of springs RBC Actin Cytoskeleton Lodish 17 21b Note these filaments are capped on both ends not shown ERM Family Members Link Actin Cytoskeleton to Membrane Associated Proteins Lodish 17 21e ERM Ezrin Radixin Moesin Lots of Protein Families Interact with Actin These are some sites on actin that bind only a few proteins Concepts Big Picture 1 Why is actin highly conserved in evolution because it has many functions and because interacts with many actin binding proteins 2 Invention is difficult adaptation is easier inventing a polymer is a rare event adapting a polymer to various functions is much easier much more frequent Actin is a Subunit of Nuclear Complexes Chromatin Remodeling Complexes Trends in Cell Biology 24 238 April 2014 Actin is a Subunit of Nuclear Complexes Chromatin Remodeling Complexes Trends in Cell Biology 24 238 April 2014
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