CHEM 3332 Lecture 24Outline of Last Lecture Synthesis and Reactions of AmidesFew reactions – fortunatelyl Reduction of Amide to AmineDehydration to Nitrile Synthesis and Reactions of NitrilesHydrolysis: (basic conditions)Reduction to AmineSpectroscopy Summary of Carboxylic Acid Derivatives Outline of Current Lecture C. Alkylation of ketone and esters (and nitriles)D. Alkylation of EnamineStork SynthesisE. Alkylation of Beta – Dicarbonyl Compounds1. Malaonic Ester SynthesisStepsMechanismExampleFormation of Cyclic carboxylic Acids with malonic ester synthesis (ring size: 3-6)2. acetoacetic Ester Synthesis:StepsExampleSynthesis ExampleII. Condensation reactionsA. Aldol CondensationExampleDehydration of alcohol productsB. Crosses (mixed):Successful crossed aldolC. Intramolecular AldolD. Clasien CondensationE. Crossed (Mixed) ClaisenThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Current
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