CHEM 3332 Lecture 23Outline of Last Lecture Chapter 21: Carboxylic Acid Derivatives (acyl derivatives and nitriles)Physical PropertiesReactivity/Interconversion of Derivatives –Nucleophilic Acyl Substitution Order of reactivity results from a combination of factors1. Basicity (stability) of the leaving group 2. Resonance stabilization of Derivative3. Steric FactorsNaming carboxylic Acid Derivatives: (From Carboxylic Acid Names)I. Acid HalidesII. AnhydridesIII. Esters IV. Amides V. NitrilesSynthesis of Reactions of Acid Chlorides (RCOCL)Synthesis and Reactions of AnhydridesCyclic AnhydridesSynthesis and Reactions of EstersCyclic EstersSapnofication:Outline of Current LectureSynthesis and Reactions of AmidesFew reactions – fortunatelyl Reduction of Amide to AmineDehydration to Nitrile Synthesis and Reactions of NitrilesHydrolysis: (basic conditions)Reduction to AmineSpectroscopy Summary of Carboxylic Acid Derivatives These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Current
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