PowerPoint PresentationSlide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Slide 11Slide 12Slide 13Slide 14Slide 15Slide 16Slide 17Slide 18Slide 19Slide 20Slide 21Slide 22Slide 23Slide 24Chapter 18: Microtubules and Intermediate Filaments18.1. Microtubule Structure and OrganizationTubulinProtofilaments and tubulesMicrotubule-organizing centers (MTOCs)Microtubule nucleation18.2. Microtubule DynamicsDynamic Instability-catastrophes and rescues18.3. Regulation of Microtubule Structure and DynamicsNeed microtubule associated proteins (MAPs) for stabilizationKinesin-13 increases depolymerization of the microtubule18.4. Kinesins and Dyneins: Microtubule-based Motor Proteins-Have 14 known classes of kinesins encoded by 45 different genesKinesin 1 structurehttps://www.youtube.com/watch?v=YAva4g3Pk6kDynein motors move organelles to the – end of the microtubuleKinesins and dyneins transport organelles and vesicles around the cell18.6. MitosisThe cell cycleG1SG2MS phaseStages of mitosisStages of mitosis (continued)Three classes of microtubules coming from the spindle poles:‘Capture’ of chromatidsRole of Ran GEFAttaching the microtubules to chromosomes and alignment during metaphase18.7. Intermediate Filaments-Different from other filaments:Structure18.8. Coordination Between Cytoskeletal