BIO 1201 1nd Edition Lecture 19 Outline of Last Lecture I.TranslationII.MutationsOutline of Current Lecture III.Sickle Cell DiseaseIV.EvolutionCurrent LectureI. Sickle Cell Diseasea. Caused by single base substitution in hemoglobin gene, which changes the protein glutamine to valineb. This changes the shape of the hemoglobin protein, making the proteins clump together and crystalizec. This changes the blood cells to a sickle shape, which is less efficient at carrying oxygend. Mutated allele is recessivee. Heterozygotes have increased resistance to malaria—more common in people of sub-Saharan African descentII. Evolution: changes that transform lifea. Darwin’s Theory of Natural Selection is the unifying principle of biologyi. AlgorithmThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.1. Fact 1: individuals vary in heritable traits because of random gene mutations2. Fact 2: Any population has potential to produce more offspring than the environment can support, leading to struggle for existence, or competition3. Conclusion: individuals with traits best suited to local environmentwill have greater reproductive successb. Evolution depends on selective pressure to pick variations that worki. Overuse of antibiotics can provide this pressure for
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