CPSC 382Organic Chem Ag Biol ProcTopic #10 - Amino Acids and Proteins 1. Amino acid structure2. Fischer system for describing the amino acid chiral carbon3. 20 protein amino acids and their properties4. Acid/base properties of amino acidsa. pKa’s for amine and carboxylate groupb. titration curve for a neutral amino acidc. zwitterion form of amino acidsd. effect of side groups on acid/base propertiese. concept of isoelectric point (pI)5. Peptidesa. structure of the peptide bond regionb. nomenclature for peptides6. Proteinsa. primary, secondary, tertiary, and quartenary structureb. disulfide bondsc. examples of protein structureGeneral amino acid structure: Fischer system applied to amino acids:Structure of protein amino acids:Acid/Base properties of amino acids:amino acid zwitterion: protonation/deprotonation of amino and carboxylic group: titration curve for a neutral amino acid:net charge on an amino acid during titration: acid/base properties of amino acids with ionizable side-chains:acidic side chainbasic side chainPeptide bond structure:Protein structure:disulfide bond
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