CPSC 382Organic Chem Ag Biol ProcTopic #6 - Nitrogen-Containind Compounds1. Aminesa. Definitionb. Classificationc. Orbital structure of the nitrogen atomd. Nomenclaturee. Physical properties of aminesf. Basicity of amines2. Amidesa. Definitionb. Nomenclaturec. Structure of the amide groupd. H-bond interaction between amides3. N-Heterocyclic compoundsa. definitionb. aromatic vs. non-aromatic ring systemsc. pyridine structured. 5-membered heterocyclic ring system-pyrrolee. Fused N-heterocyclic ring systems(1) quinoline(2) indolef. Poly-N Heterocyclic ring systems(1) imidazole(2) purine4. Neuro- and Psycho-Active drugs with nitrogen structures5. Role of N-Heterocyclic Molecules in Cell Energy Metabolism (Oxidation/Reduction)a. NAD(P)H/NAD(P)+b. FADH/FAD+AMINES:Classification:Orbital structure around nitrogen:Configuration change around nitrogen:Nomenclature:Physical properties of amines:Amines as bases:AMIDES:nomenclature:structure of the amide group (resonance): H-bonding between amides: Amide boiling points:N-HETEROCYCLIC COMPOUNDS:Pyridine: pyridine orbital structure:pyridine H-bond interaction with water: Examples of pyridine-based molecules: 5-membered N-heterocyclic ring system (pyrrole): Fused N-heterocyclic ring systems:Quinoline:Indole: Poly-N heterocyclic ring systems:Imadizole:Purine:Neuro- and Psycho-active drugs with nitrogen structures:Role of N-heterocyclic compounds in cell energy metabolism