Sn2 Reactions

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CH 220 1st Edition Lecture 17 Outline of Current Lecture I. Sn2 reactions II. The leaving group III. Sn1 reactions Current Lecture I. Sn2 reactions a. If you have larger neightbors around the C, it is harder for the nucleophile to react with it. The nucleophile favors small neighbors. Smallest possible neighbors are hydrogens. Reaction Substrates Solvents Nucleophile Stereochemistry Sn2 Methyl>1>2 (never 3) Acetone or DMSO NaCl, NaBr, NaI, NaCN, KCl, KBr, KI, KCN R -> S S -> R II. The leaving group a. If a group is willing to leave, it will leave faster b. Stable anions that are weak bases are usually excellent leaving groups c. The more electronegative, the harder it is to leave These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.



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