MCB 100 1st Edition Lecture 29 Outline of Last Lecture I. Factors affecting the development of wound infections II. Some microorganisms that cause infections Outline of Current Lecture I. BacillusCurrent LectureI. Bacillusa. (rod)b. Aerobes or facultativec. Heat resistant endosporesi. Examples:1. Bacillus anthracis- causes anthrax, a fatal lung infection2. Bacillus stearothermophilus- thermophile that grows at 65 degrees C3. Bacillus thuringiensis- makes insecticidal toxin (BT toxin)4. Bacillus licheniformis- a denitrifying bacteria (reduces nitrate) b. Bacillus anthracis i. Primarily a herbivore disease (sheep and cattle especially)ii. Problem in nations where animal vaccination is not practicaliii. Virulence factors include: a capsule made of glutamic acid and toxins (edema factor, lethal factor, and protective antigen)b. Inhalation anthraxi. Initial flu like symptomsii. Treatment is often too late to save the patient because the toxins are enzymes, even if the bacteria are killed the toxins keep on working to kill the patientiii. Very high mortality rate in untreated casesb. Cutaneous anthraxi. Infects minor woundsii. Necrotic effects on surrounding tissuesiii. AKA: wool sorter's diseaseiv. Untreated mortality rate is 20% b. Gastrointestinal anthraxi. Infects gut, due to eating contaminated meatb. Bacillus stearothermophilusThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.i. A thermophile that is involved in hay spoilage (wet hay can lead to barn fires due to the heat released by microbial metabolism)b. Bacillus thuringiensisi. Produces a toxin that kills insects but does not harm mammalsii. Used as an organic method of controlling insect pestsb. Bacillus licheniformisi. Synthesizes bacitracin- an antibiotic that inhibits peptidoglycan synthesis by interfering with the movement of precursor groups through the cell membraneto the cell wallii. Common soil bacterium capable of reducing
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