MCB 100 1st Edition Lecture 28 Outline of Last Lecture I. Classical traits used to identify and group microorganismsII. Classification based on microscopic morphologyIII. Genetic traits used to classify microorganisms IV. Bacteria, archaea, eukaryotesV. Traits of archaeaVI. MethanogensVII. Extremophiles- halophilesVIII. BacteriaOutline of Current Lecture I. Factors affecting the development of wound infections II. Some microorganisms that cause infections Current LectureI. Factors affecting the development of wound infectionsa. Virulence of contaminating organismb. Size of contaminated dosec. Extent of tissue damage at wound sited. Health status of wounded persone. Topical infection: an infection that is limited to the skin, nails, mucous membranes, hair, etc. f. Systematic infection: an infection that spreads throughout the body II. Microorganisms that cause infectionsa. Clostridium perfringesi. Spores are common in soil wound infectionii. Causes gas granene if it infects a woundiii. Produces a number of necrotizing toxins that kill tissuesiv. Anaerobic, spore forming, gram positive rodv. Found in soil, animal feces, meat and poultry contaminated at slaughtervi. Also can cause food borne infection!vii. Exotoxin produced in intestines after ingesting contaminated foodviii. Symptoms: abdominal pain. Diarrhea b. Clostridium difficilei. May be found in low numbers in the human gutii. Naturally resistant to several antibioticsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.iii. May multiply in patients on antibiotic therapyiv. Produces toxinsv. May cause antibiotic induced diarrhea vi. Is a major cause of colitis following antibiotic use, especially in hospitals vii. Makes two toxins called A&Bviii. Tissue destruction in the colon causes formation of a plague-like pseudomembraneix. Symptoms: watery diarrhea, with no blood x. To treat, stop antibiotic therapy, give probiotics xi. Colonizes the colon but generally does not become very numerous because it does not compete well with the natural gut floraxii. Is naturally resistant to several antibiotics. Antibiotic therapy allows the bacteria to multiply to high numbersxiii. Toxins can cause diarrheal diseaseb. Ruminoccocus flavefaciens i. Gram positive, anaerobic, gut microorganism now grouped in the Clostridia classii. Helps ruminant animals digest
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